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Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
- 专利权人:
- ABBVIE BAHAMAS LTD.
- 发明人:
- BRUNCKO, MILAN,DING, HONG,DOHERTY, GEORGE,ELMORE, STEVEN,HASVOLD, LISA,HEXAMER, LAURA,KUNZER, AARON R.,SONG, XIAOHONG,SOUERS, ANDREW J.,SULLIVAN, GERARD,TAO, ZHI-FU,WANG, GARY T.,WANG, LE,WANG, XILU,W
- 申请号：
- ES10784398
- 公开号：
- ES2546135T3
- 申请日:
- 2010.11.22
- 申请国别(地区):
- ES
- 年份:
- 2015
- 代理人:
- 摘要：
- A compound or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of: trans-4 - {[(4 - {[4- (4 - {[2- (4-chlorophenyl) -4), 4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -2- (1 H -pyrrolo [2,3- b] pyridin-5-yloxy) benzoyl] sulfamoyl} -2-nitrophenyl) amino ] methyl} methyl cyclohexanecarboxylate； Trans-4 - {[(4 - {[4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) - 2- (1H-pyrrolo [2,3- b] pyridin-5-yloxy) benzoyl] sulfamoyl-2-nitrophenyl) amino] methyl} cyclohexanecarboxylic acid； N- (4 - {[4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -2- (1H- pyrrolo [2,3-b] pyridin-5- yloxy) benzoyl] sulfamoyl} -2-nitrophenyl) -4-cyanopiperidin-1-carboxamide； 4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -N - {[4 - ({[cis-4 - (methoxymethyl) cyclohexyl] methyl} amino) -3-nitrophenyl] sulfonyl} -2- (1 H -pyrrolo [2,3-b] pyridin-5-yloxy) benzamide； 4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -N - {[4 - ({[trans-4 - (methoxymethyl) cyclohexyl] methyl} amino) -3-nitrophenyl] sulfonyl} -2- (1 H -pyrrolo [2,3-b] pyridin-5-yloxy) benzamide； 4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -2- (1H-pyrrolo [2,3-b ] pyridin-5-yloxy) -N- {[1- (tetrahydro-2H-pyran-4-ylmethyl) -1H-benzotriazol-5-yl] sulfonyl} benzamide； N - ({5-chloro-6 - [(2-oxo-1-oxa-3-azaspiro [4,5] dec-8-yl) methoxy] pyridin-3-yl} sulfonyl) -4- (4- {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -2- (1H-pyrrolo [2,3-b] pyridin-5- yloxy) benzamide； N- (4 - {[4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -2- (1H- pyrrolo [2,3-b] pyridin-5- yloxy) benzoyl] sulfamoyl} -2-nitrophenyl) -4-methoxypiperidin-1-carboxamide； N - ({5-chloro-6 - [(2-methyl-4,5,6,7-tetrahydro-1,3-benzothiazol-5-yl) methoxy] pyr
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
