BRUNCKO MILAN,WANG XILU,HEXAMER LAURA,WANG GARY T,ELMORE STEVEN,SOUERS ANDREW J,DING HONG,WENDT MICHAEL,HASVOLD LISA,DOHERTY GEORGE,SONG XIAOHONG,MANTEI ROBERT,SULLIVAN GERARD,HANSEN TODD M,TAO ZHI-FU
申请号：
NZ59570810
公开号：
NZ595708A
申请日:
2010.05.26
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
595708 Disclosed herein are compounds of formula II which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein. In specific embodiments the compound is 4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-({ 3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl} sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy) benzamide or trans-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-({ 4-[(4-morpholin-4-ylcyclohexyl)amino]-3-nitrophenyl} sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide, which is useful to treat cancers.
