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Isothiazole derivatives as GPR120 agonists for the treatment of type II diabetes
专利权人:
Janssen Pharmaceutica NV
发明人:
ILLIG, Carl R.,PLAYER, Mark R.,ZHANG, Xuqing
申请号:
ES14714057
公开号:
ES2673578T3
申请日:
2014.03.07
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of Formula (I) ** Formula ** wherein R 1 is selected from the group consisting of cyclopropyl, 4-methylcyclohex-1-en-1-yl, trifluoromethyl and phenyl; wherein phenyl is optionally independently substituted with one or two substituents that are C1-2 alkyl, methoxy, chloro, fluoro or trifluoromethyl; Q is selected from the group consisting of q1 to q3 ** Formula ** where RB is absent, or RB is one to four substituents independently selected from the group consisting of methyl, ethyl, methoxy, fluoro, 1-fluoroethyl, 1,1 -difluoroethyl, difluoromethyl, trifluoromethyl and trifluoromethoxy; with the proviso that RB is not more than one of ethyl, methoxy, 1-fluoroethyl, 1,1-difluoroethyl, difluoromethyl, trifluoromethyl or trifluoromethoxy; RC is ** Formula ** R2 is hydroxymethyl or carboxy; R4 is hydrogen or methyl; G is i) chlorine; Ii) pyridinyl optionally independently substituted with one or two substituents selected from the group consisting of C1-2 alkyl, C1-2 alkoxy, chlorine and fluorine; iii) thiophenyl optionally substituted with a chlorine substituent; iv) 4- (RA) phenyl, wherein RA is selected from the group consisting of hydrogen, C1-3 alkyl, C1-2 alkoxy, fluorine, chlorine, cyano, trifluoromethyl, methylcarbonyl and cyclopropyl; wherein said phenyl of group iv) is optionally independently further substituted with one or two additional fluoro or methoxy substituents; v) thiazolyl optionally substituted with a trifluoromethyl, chloro, methyl or methoxy substituent; or vi) isothiazolyl optionally substituted with a trifluoromethyl, chloro, methyl or methoxy substituent; or an enantiomer, diastereomer or pharmaceutically acceptable salt form thereof.Un compuesto de Fórmula (I)**Fórmula** donde R1 se selecciona del grupo que consiste en ciclopropilo, 4-metilciclohex-1-en-1-ilo, trifluorometilo y fenilo; en 20 donde fenilo está opcionalmente sustituido independientemente con uno o dos sustituyentes que son alquilo C1-2, metoxi, cloro, fluoro o trifluor
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