ADAM, Jean-Michel,BISSANTZ, Caterina,GRETHER, Uwe,KIMBARA, Atushi,NETTEKOVEN, Matthias,ROEVER, Stephan,ROGERS-EVANS, Mark
申请号：
ES12780208
公开号：
ES2553704T3
申请日:
2012.11.05
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of the formula (I) ** Formula ** in which: A is alkyl, hydroxyalkyl, -CH2C (O) -, -C (O) -, -SO2- or is absent； R1 is hydrogen, alkyl, haloalkyl, hydroxy, alkoxy, haloalkoxy, phenyl, halophenyl, alkoxyphenyl, haloalkylphenyl, haloalkoxyphenyl, (halo) (haloalkyl) phenyl, cyanophenyl, hydroxyalkoxyphenyl, alkylsulfonylphenyl, alkylsulfonylaminophenyl, cycloalkylalkyl, cycloalkylalkyl, cycloalkyloxylalkyl, cycloalkyloxy, alkyloxyphenyl, cycloalkyloxylalkyl, cycloalkyloxylalkyl ) (alkyl) [1,2,4] tri-azolyl, (halo) - (dialkylamino) pyridinyl, (alkyl) (oxy) -pyridinyl, nitro-benzo [1,2,5] oxadiazolylamino-pyridinyl, heterocyclyl, alkylheterocyclyl , hydroxy-heterocyclyl, alkylheterocyclyl, heteroaryl, haloheteroaryl, alkylheteroaryl, cycloalkylheteroaryl or haloalkyl heteroaryl, said heterocyclyl is a three to eight membered carbocyclic ring containing at least one nitrogen or oxygen atom, and said heteroaryl is pyridinyl, pyrazole , furazanyl, tetrazolyl or triazolyl； R2 is halogen, -NR3R4 or -OR5； one of R3 and R4 is hydrogen or alkyl and the other is alkyl or cycloalkyl； or R3 and R4 together with the nitrogen atom to which they are attached form a substituted heterocyclyl or heterocyclyl, said heterocyclyl is morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, 2-oxa-6-azaspiro [3.3] heptyl, azetidinyl, thiazolidinyl, thiomorinyl, thiomorinyl, thiomorinyl dioxothiomorpholinyl, oxazepanyl, 2-oxa-6-azaspiro [3.4] octyl, 6-oxa-1- azaspiro [3.3] heptyl, 2-oxa-5-azaspiro [3.4] -octyl, isoxazolidinyl, aziridinyl, dioxoisothiazolidinyl or oxop Substituted heterocyclyl is a heterocyclyl substituted one to four times by substituents independently selected from alkyl, halogen, hydroxyl, alkoxy, hydroxyalkyl, carboxy, alkoxyalkyl, cyano, alkylamino, dialkylamino, alkylcarbonylamino, alkylcarbonyl (alkylamino), phenyl, alkoxycarbonyl, aminoalkyl, aminoalkyl alkylpyrazolyl and alkylisoxazolyl； R5 is alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl or oxetanyl； or a pharmac
