BISSANTZ, CATERINA,GRETHER, UWE,KIMBARA, ATSUSHI,NETTEKOVEN, MATTHIAS,ROEVER, STEPHAN,ROGERS-EVANS, MARK
申请号：
ES12794684
公开号：
ES2550967T3
申请日:
2012.11.22
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of the formula (I) ** Formula ** in which: A is alkylene, hydroxyalkylene, -CH2C (O) -, -C (O) -, -SO2- or is absent； R1 is hydrogen, alkyl, haloalkyl, hydroxy, alkoxy, haloalkoxy, phenyl, halophenyl, alkoxyphenyl, haloalkylphenyl, haloalkoxyphenyl, cyanophenyl, hydroxyalkoxyphenyl, alkylsulfonylphenyl, alkylsulfonylaminophenyl, (halo) (haloalkyl) phenyl, alkoxy, phenyl, alkoxy cycloalkyl, cycloalkylalkoxy, amino, heterocyclyl, alkylheterocyclyl, hydroxyheterocyclyl, alkylheterocyclyl, heteroaryl, haloheteroaryl, alkylheteroaryl, (alkyl) (alkylsulfonyl) heteroaryl, (halo) (alkylamino) heteroaryl, haloalkyl-heteroalkyl-1,2-alkyl-heterohenyl-1-cycloalkyl-heteroalkyl-1-cycloalkyl-heteroalkyl-1-cycloalkyl-heteroalkyl-1-cyclohenyl-heteroalkyl-1-cycloalkyl-heteroalkyl-1-cycloalkyl-cycloalkyl-1-cycloalkyl group oxadiazolyl-aminoheteroaryl, said heterocyclyl is a carbocyclic ring of three to eight links containing at least one nitrogen or oxygen atom, and said heteroaryl is pyridinyl, pyrazolyl, oxadiazolyl, furazanyl, tetrazolyl, triazolyl or oxypyridinyl； R2 is alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, cycloalkoxyalkyl, cycloalkylalkoxy, haloalkoxy, alkoxy or alkylamino； R3 is halogen or -NR4R5； one of R4 and R5 is hydrogen or alkyl and the other is alkyl or cycloalkyl； or R4 and R5 together with the nitrogen atom to which they are attached form a substituted heterocyclyl or heterocyclyl, said heterocyclyl is morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, 2-oxa-6-azaspiro [3.3] heptyl, azetidinyl, thiazolidinyl, thiomorinyl, thiomorinyl, thiomorinin dioxothiomorpholinyl, oxazepanyl, 2-oxa-6-azaspiro [3.4] octyl, 6-oxa-1-azaspiro- [3.3] heptyl, 2-oxa-5-aza-spiro [3.4] -octyl, isoxazolidinyl, aziridinyl or dioxoisothiazolidinyl said substituted heterocyclyl is a heterocyclyl substituted one to four times by substituents independently selected from alkyl, halogen, hydroxyl, alkoxy, hydroxyalkyl, carboxyl, alkoxyalkyl, cyano and alkylcarbonylamino； or a ph
