BLANCO-PILLADO, MARIA-JESUS,COHEN, MICHAEL,FILLA, SANDRA,HUDZIAK, KEVIN,KOHLMAN, DANIEL,BENESH, DANA,VICTOR, FRANTZ,XU, YAO-CHANG,YING, BAI-PING,ZACHERL, DEANNA,ZHANG, DEYI,MATHES, BRIAN MICHAEL
申请号：
AT04780442
公开号：
AT538093T
申请日:
2004.09.03
申请国别(地区):
AT
年份:
2012
代理人:
摘要：
The present invention relates to compounds of formula I: (I) or a pharmaceutically acceptable acid addition salt thereof, where； X is C(R<；SUP>；3c<；/SUP>；- or N-； R<；SUP>；1 <；/SUP>；is C<；SUB>；2<；/SUB>；-C<；SUB>；6 <；/SUB>；alkyl, substituted C<；SUB>；2<；/SUB>；-C<；SUB>；6 <；/SUB>；alkyl, C<；SUB>；3<；/SUB>；-C<；SUB>；7 <；/SUB>；cycloalkyl, substituted C<；SUB>；3<；/SUB>；-C<；SUB>；7 <；/SUB>；cycloalkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle； R<；SUP>；2 <；/SUP>；is hydrogen, C<；SUB>；1<；/SUB>；-C<；SUB>；3 <；/SUB>；n-alkyl, C<；SUB>；3<；/SUB>；-C<；SUB>；6 <；/SUB>；cycloalkyl-C<；SUB>；1<；/SUB>；-C<；SUB>；3 <；/SUB>；alkyl, or a group of formula II (II) provided that when R<；SUP>；1 <；/SUP>；is C<；SUB>；2<；/SUB>；-C<；SUB>；6 <；/SUB>；alkyl or substituted C<；SUB>；2<；/SUB>；-C<；SUB>；6 <；/SUB>；alkyl, R<；SUP>；2 <；/SUP>；is hydrogen or methyl； R<；SUP>；3a<；/SUP>；, R<；SUB>；3b<；/SUB>；, and, when X is C(R<；SUP>；3c<；/SUP>；)-, R<；SUP>；3c<；/SUP>；, are each independently hydrogen, fluoro, or methyl, provided that no more than one of R<；SUP>；3a<；/SUP>；, R<；SUP>；3b<；/SUP>；, and R<；SUP>；3c <；/SUP>；may be other than hydrogen； R<；SUP>；4 <；/SUP>；is hydrogen or C<；SUB>；1<；/SUB>；-C<；SUB>；3 <；/SUB>；alkyl； R<；SUP>；5 <；/SUP>；is hydrogen, C<；SUB>；1<；/SUB>；-C<；SUB>；3 <；/SUB>；alkyl, or C<；SUB>；3<；/SUB>；-C<；SUB>；6 <；/SUB>；cycloalkylcarbonyl, provided that when R<；SUP>；3a <；/SUP>；is other than hydrogen, R<；SUP>；5 <；/SUP>；is hydrogen； R<；SUP>；6 <；/SUP>；is hydrogen or C<；SUB>；1<；/SUB>；-C<；SUB>；6 <；/SUB>；alkyl； and n is an integer from 1 to 6 inclusively. The compounds of the present invention are useful for activating 5-HT<；SUB>；1F <；/SUB>；receptors, inhibiting neur
