Daniel T. Kohlman;Bai-Ping Ying;Michael P. Cohen;Sidney X. Liang;Yao-Chang Xu;Deanna P. Zacherl;Deyi Zhang;Frantz Victor
发明人:
Michael P. Cohen,Daniel T. Kohlman,Sidney X. Liang,Frantz Victor,Yao-Chang Xu,Bai-Ping Ying,Deanna P. Zacherl,Deyi Zhang
申请号：
US13363895
公开号：
US20120329820A1
申请日:
2012.02.01
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to compounds of formula I:or pharmaceutically acceptable acid addition salts thereof, where；R1 is C1-C6 alkyl, substituted C1-C6 alkyl, C3-C7 cycloalkyl, substituted C3-C7 cycloalkyl, C3-C7 cycloalkyl-C1-C3 alkyl, substituted C3-C7 cycloalkyl-C1-C3 alkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle；R2 is hydrogen, C1-C3 alkyl, C3-C6 cycloalkyl-C1-C3 alkyl, or a group of formula IIR3 is hydrogen or C1-C3 alkyl；R4 is hydrogen, halo, or C1-C3 alkyl；R5 is hydrogen or C1-C3 alkyl；R6 is hydrogen or C1-C6 alkyl； andn is an integer from 1 to 6 inclusively.The compounds of the present invention are useful for activating 5-HT1F receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal. The present invention also relates to a process for the synthesis of intermediates in the synthesis of compounds of Formula I.
