YONG-MI CHOI-SLEDESKI,PATRICK WAI-KWOK SHUM,DAVID STEFANY,KEITH J. HARRIS,JOACY C. AGUIAR,STEPHAN REILING,GREGORY B. POLI,ZHICHENG ZHAO,GREGORY STOKLOSA,CHARLES GARDNER
申请号：
MX2012010035
公开号：
MX2012010035A
申请日:
2011.03.15
申请国别(地区):
MX
年份:
2012
代理人:
摘要：
The present invention is directed to a substituted pyrimidine compound of formula (I) as set forth herein, or an enantiomer thereof, or a prodrug or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising such a compound. The invention also includes a method of treatment of a patient by the administration of a pharmaceutically effective amount of such a compound. Formula (I), wherein m and n, independently of each other, are selected from the integers 0, 1, 2 or 3 X and Y, independently of each other, are selected from CR1R2, NR1 or O, wherein X and Y cannot both be O or X and Y, taken together with the bond between them, form a phenyl group optionally substituted by one to four R3 groups each Z, independently of each other, is CR1R2 R1, R2 and R3, independently of each other, are selected from the group consisting of H, halogen, aryl, amino, optionally substituted alkyl, optionally substituted alkoxy, and carboxy wherein optionally substituted alkyl, may be substituted by one to three of the same or different of halogen, carboxy, cyano, hydroxy, amino or aryl.La presente invención se refiere a un compuesto de pirimidina sustituida de la fórmula (I): (ver fórmula (I)) o un enantiómero del mismo, o un profármaco o una sal del mismo farmacéuticamente aceptable, o una composición farmacéutica que comprende un compuesto de este tipo. La invención incluye también un método de tratamiento de un paciente mediante la administración de una cantidad farmacéuticamente eficaz de un compuesto de este tipo.
