HARRIS, KEITH J.,AGUIAR, JOACY C.,SHUM, PATRICK WAI-KWOK,ZHAO, ZHICHENG,POLI, GREGORY B.,STOKLOSA, GREGORY,CHOI-SLEDESKI, YONG-MI,REILING, STEPHAN,STEFANY, DAVID,GARDNER, CHARLES
申请号：
SG2012063913
公开号：
SG183533A1
申请日:
2011.03.15
申请国别(地区):
SG
年份:
2012
代理人:
摘要：
The present invention is directed to a substituted pyrimidine compound of formula (I) as set forth herein, or an enantiomer thereof, or a prodrug or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising such a compound. The invention also includes a method of treatment of a patient by the administration of a pharmaceutically effective amount of such a compound. Formula (I), wherein m and n, independently of each other, are selected from the integers 0, 1, 2 or 3； X and Y, independently of each other, are selected from CR1R2, NR1 or O, wherein X and Y cannot both be O； or X and Y, taken together with the bond between them, form a phenyl group optionally substituted by one to four R3 groups； each Z, independently of each other, is CR1R2； R1, R2 and R3, independently of each other, are selected from the group consisting of H, halogen, aryl, amino, optionally substituted alkyl, optionally substituted alkoxy, and carboxy； wherein optionally substituted alkyl, may be substituted by one to three of the same or different of halogen, carboxy, cyano, hydroxy, amino or aryl.
