HARRIS KEITH J,AGUIAR JOACY C,SHUM PATRICK WAI KWOK,ZHAO ZHICHENG,POLI GREGORY B,STOKLOSA GREGORY,CHOI SLEDESKI YONG MI,REILING STEPHAN,STEFANY DAVID,GARDNER CHARLES
申请号：
IN7625/CHENP/2012
公开号：
IN2012CN07625A
申请日:
2012.09.04
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
121312123The present invention is directed to a substituted pyrimidine compound of formula (I) as set forth herein or an enantiomer thereof or a prodrug or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising such a compound. The invention also includes a method of treatment of a patient by the administration of a pharmaceutically effective amount of such a compound. Formula (I) wherein m and n independently of each other are selected from the integers 0 1 2 or 3 X and Y independently of each other are selected from CRR NR or O wherein X and Y cannot both be O or X and Y taken together with the bond between them form a phenyl group optionally substituted by one to four R groups each Z independently of each other is CRR R R and R independently of each other are selected from the group consisting of H halogen aryl amino optionally substituted alkyl optionally substituted alkoxy and carboxy wherein optionally substituted alkyl may be substituted by one to three of the same or different of halogen carboxy cyano hydroxy amino or aryl.
