Harris, Keith J.,Aguiar, Joacy C.,Shum, Patrick Wai-Kwok,Zhao, Zhicheng,Poli, Gregory B.,Stoklosa, Gregory,Choi-Sledeski, Yong-Mi,Reiling, Stephan,Stefany, David,Gardner, Charles
申请号：
AU2011227417
公开号：
AU2011227417A1
申请日:
2011.03.15
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention is directed to a substituted pyrimidine compound of formula (I) as set forth herein, or an enantiomer thereof, or a prodrug or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising such a compound. The invention also includes a method of treatment of a patient by the administration of a pharmaceutically effective amount of such a compound. Formula (I), wherein m and n, independently of each other, are selected from the integers 0, 1, 2 or 3； X and Y, independently of each other, are selected from CRR, NR or O, wherein X and Y cannot both be O； or X and Y, taken together with the bond between them, form a phenyl group optionally substituted by one to four R groups； each Z, independently of each other, is CRR； R, R and R, independently of each other, are selected from the group consisting of H, halogen, aryl, amino, optionally substituted alkyl, optionally substituted alkoxy, and carboxy； wherein optionally substituted alkyl, may be substituted by one to three of the same or different of halogen, carboxy, cyano, hydroxy, amino or aryl.
