SINGH, Rajinder,DUNCTON, Matthew,ZHANG, Jing,ALVAREZ, Salvador,TSO, Kin,HOLLAND, Sacha,YEN, Rose,KOLLURI, Rao,HECKRODT, Thilo,CHEN, Yan,MASUDA, Esteban,LI, Hui,PAYAN, Donald G.,KELLEY, Ryan
申请号：
ES13773141
公开号：
ES2658395T3
申请日:
2013.04.04
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula (VI): ** (See formula) ** in which R1, R2, R3, R4, R5, and R6 are independently selected from hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, acyl, acylamino , acyloxy, amino, substituted amino, aminoacyl, aminoacyloxy, oxyaminoacyl, azido, cyano, halogen, hydroxy, carboxy, carboxylalkyl, thiol, thioalkoxy, substituted thioalkoxy, aryl, aryloxy, hydroxyamino, alkoxyamino, nitro, -SO-alkyl, -SO -substituted alkyl, -SO-aryl, -SO-heteroaryl, -SO2-alkyl, -SO2-substituted alkyl, -SO2-aryl and -SO2-heteroaryl； or R1 and R2 together form an oxo group； or R3 and R4 together form an oxo group； or R5 and R6 together form an oxo group； R7, R8, R9, and R10 are independently selected from hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, acyl, acylamino, acyloxy, amino, substituted amino, aminoacyl, aminoacyloxy, oxyaminoacyl, azido, cyano, halogen, hydroxy, carboxyl , carboxylalkyl, thiol, thioalkoxy, substituted thioalkoxy, aryl, aryloxy, hydroxyamino, alkoxyamino, nitro, -SO-alkyl, -SO-substituted alkyl, -SO-aryl, -SO-heteroaryl, -SO2-alkyl, -SO2-alkyl substituted, -SO2-aryl and -SO2-heteroaryl； or R7 and R8 together form an oxo group； or R9 and R10 together form an oxo group； R11 is selected from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, hydroxy, alkoxy, substituted alkoxy, amino, substituted amino, carboxyl, carboxylic ester, cyano, halogen, thiol, thioalkoxy, substituted thioalkoxy, acyl, aminoacyl, nitro, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, -SO-alkyl, -SO-substituted alkyl, -SO-aryl, -SO-heteroaryl, -SO2-alkyl, -SO2-substituted alkyl, -SO2-aryl and -SO2-heteroaryl； R20 is selected from hydrogen, alkyl and substituted alkyl； G is -NY2Ar1； Y1 and Y2 are independently selected from hydrogen, alkyl and substituted alkyl； and Ar1 is selected from aryl, substituted aryl, heteroaryl, and substituted heteroaryl； or a salt or stereoisomer thereof； wherein: "alkyl" is a monovalent satura
