Compounds of the formula ** Formula ** in which: A1 is CR13 or N； A2 is CR14 or N； R1 and R2 are independently selected from each other from the group consisting of hydrogen, C1-7 alkyl, halogen, halogen-C1-7 alkyl, cyano and C1-7 alkoxy； R13 and R14 are independently selected from each other from the group consisting of hydrogen, C1-7 alkyl, halogen, halogen-C1-7 alkyl, cyano, C1-7 alkoxy, amino and (C1-7 alkyl) -sulfanyl； R3 is selected from the group consisting of hydrogen, C1-7 alkyl, halogen, halogen- C1-7 alkyl, cyano- C1-7 alkoxy, cyano, C3-7 cycloalkyl, N-heterocyclyl, five-link heteroaryl, phenyl and -NR15R16, wherein R15 and R16 are independently selected from each other from hydrogen, C1-7 alkyl and C3-7 cycloalkyl； R4 is selected from the group consisting of hydrogen, C1-7 alkyl, halogen-C1-7 alkyl and C3-7 cycloalkyl； or R3 and R4 or R3 and R14 together are -X- (CR17R18) n- and are part of a ring； wherein X is chosen from the group consisting of -CR19R20-, O, S, C>； = O and NR21； R17 and R18 are independently selected from each other between hydrogen or C1-7 alkyl； R19 and R20 are independently selected from each other from the group consisting of hydrogen, C1-7 alkyl, (C1-7 alkoxy) -carbonyl, unsubstituted heterocyclyl and heterocyclyl substituted by one or two groups chosen from C1-7 alkyl and 20 halogen , or R19 and R20 together with the C atom to which they are attached form a cyclopropyl or oxetanyl ring or together form a group>； = CH2 or>； = CF2； R21 is selected from the group consisting of hydrogen, C1-7 alkyl, halogen-C1-7 alkyl； C 3-7 cycloalkyl or (C 3-7 cycloalkyl) -C 1-7 alkyl, said C 3-7 cycloalkyl is unsubstituted or substituted by carboxy-C 1-7 alkyl or (C 1-7 alkoxy) -carbonyl； heterocyclyl, heterocyclyl-C1-7 alkyl, heteroaryl, heteroaryl-C1-7 alkyl, carboxy-C1-7 alkyl, (C1-7 alkoxy) -carbonyl-C1-7 alkyl, (C1-7 alkyl) -carbonyloxy-C1 alkyl -7, 30 (C1-7 alkyl) -sulfonyl, phenyl, said phenyl is unsubstituted or substituted by carbox
