The compounds of formula (1) are used to treat inflammation and autoimmune disorders. Drug composition, preparation process and use as interlequina modulator - Iraq, claim 1: a formula compound (1), wherein Q represents AR or het； e reaction - (CH2) MCO -,- (CH2) mSO2, - (CH2) mNHCO- or a single bond； R1 denotes H, OH, NH-C1-6 alkyl, O-C1-6 alkyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, Cyc, Hal, Het1, O-Het1, CO-Het1, NH -Het1, CO-Ar1, O-Ar1, Ar1, NH-Ar1, - (CH2) qHet1, -CONH- (CH2) qHet1, -CONH-Het1, - (CH2) qO-Het1, - (CH2) qO- Ar1, - (CH2) qAr1, -CONH- (CH2) qAr1, -CONH-Ar1, -CONH-cycloalkyl C3-6, - (CH2) qHal, - (CH2) qCyC, CF3, - (CH2) sNH- ( CH2) q-Het1, - (CH2) sNH- (CH2) q-Ar1, wherein NH-C1-6alkyl, O-C1-6alkyl, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6 cycloalkyl may be substituted with 1 to 3 groups independently selected from O-C1-3alkyl, OH, CONH2, NH2； R2 denotes H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl,Hal, CF3, prior to h； R3 for het1, AR1, nrab, COOH, - (CH2) qhet1, - (CH2) qr1, - (CH2) qnrab, - (CH2) qcooh or C1-6 tar, where 1 to 3 hydrogen atoms can be independently replaced by Oh or CF3； R4 for H, C1-6 tar, alquenilo c2-6, Hal； RA for H, C1-6, linear resin, ral, ramih； Hetb, ARB, Co hetb, CO ARB, UN cycloquilo C3-8, or a coil C1-6 linear or separable tar, in which one or three hydrogen atoms can be replaced by hetb, ARB, NH2, n (C1-6 tar) 2, NH (C1-6 tar),1. N (C1-6 tar) (cycloquilo C3-8)；NH (cicloalquilo C3-8)Or (C1-6 asphalt)CN, OH, CF3, Hal； n is 0, 1, 2, 3, or 4； m is 0, 1, 2, 3 or 4； q is 1, 2, or 3； s is 0, 1, 2 or 3； Hal denotes Cl, Br, I, F, preferably Cl or F； Ar denotes a fused divalent or bicyclic monocyclic arylene group having 6 to 14 carbon atoms, which may also be substituted with 1 to 4 substituents selected from Hal, C1-6 alkyl, - (CH2) mO-C1-6 alkyl, CN , OH, NO2, CF3, - (CH2) mCOOH, - (CH2) mCOO-C1-6 alkyl； Het denotes a fused divalent monocyclic or bicyclic monocyclic, saturated or aromatic heterocyclic group having 1 to 5 he
