UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG;GOETHE-UNIVERSITY
发明人:
ABDULLAH ELY,JENNIFER D'ONOFRIO,JOACHIM W. ENGELS,JOLANTA BRZEZINSKA,JUSTIN HEAN,MAXIMILIAN C.R. BUFF,MUSA MARIMANI,PATRICK ARBUTHNOT,STEFAN BERNHARDT
申请号：
BR112014010134
公开号：
BR112014010134A2
申请日:
2012.10.26
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
Abstract: This invention relates to modified short interfering rna (sirna) nucleic acid molecules, particularly sirna's which have been modified by the addition of a 2-guanidinopropyl (gp) modified nucleoside. in particular the invention relates to modified sirnas which are capable of silencing target sequences, methods of treating and preventing infection by using the sirnas, medications containing the sirnas and use of the sirnas. _______________________________________________________________________ translation of abstract patent summary: "inhibition of viral genetic expression". This invention relates to modified short interfering mRNA (sirna) nucleic acid molecules, in particular sirens which have been modified by the addition of a modified 2-o-guanidinopropyl (gp) nucleoside. in particular, the invention relates to modified sirens which are capable of silencing target sequences, methods of treating and preventing infection through the use of sirens, siren-containing medicaments and the use of sirens.abstract: this invention relates to modified short interfering rna (sirna) nucleic acid molecules, particularly sirna's which have been modified by the addition of a 2 -0- guanidinopropyl (gp) modified nucleoside. in particular the invention relates to modified sirnas which are capable of silencing target sequences, methods of treating and preventing infection by using the sirnas, medicaments containing the sirnas and use of the sirnas. _______________________________________________________________________ tradução do resumo resumo patente de invenção: "inibição da expressão genética viral". esta invenção refere-se às moléculas de ácido nucléico de rna interferente curto (sirna) modificado, em particular sirnas que foram modificados pela adição de um nucleosídeo modificado de 2-o-guanidinopropila (gp). em particular, a invenção refere-se aos sirnas modificados que são capazes de silenciar as sequências alvo, aos métodos de tratamento e prevenção da infecção atrav
