The present invention provides compounds, compositions and methods that modulate the expression of human p21 using RNA interference. RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumors. A series of siRNAs comprising one or more modified or chemically modified nucleotides are provided, and advantageous structures include siRNAs having 2'deoxynucleotides as well as other nucleotide modifications in the seed region. [Selection figure] None本発明は、RNA干渉を利用してヒトp21の発現を調節する化合物、組成物及び方法を提供する。RNA干渉分子は悪性腫瘍等の疾患の予防又は治療方法に利用できる。１以上の修飾又は化学的修飾ヌクレオチドを含む一連のsiRNAが提供され、有利な構造にはシード領域に2’デオキシヌクレオチド並びに他のヌクレオチド修飾を有するsiRNAが含まれる。【選択図】無し
