UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG;GOETHE-UNIVERSITY
发明人:
ARBUTHNOT, PATRICK,HEAN, JUSTIN,ELY, ABDULLAH,MARIMANI, MUSA,BRZEZINSKA, JOLANTA,D'ONOFRIO, JENNIFER,BUFF, MAXIMILIAN C. R.,ENGELS, JOACHIM W.,BERNHARDT, STEFAN
申请号：
CA2853609
公开号：
CA2853609A1
申请日:
2012.10.26
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
This invention relates to modified short interfering RNA (siRNA) nucleic acid molecules, particularly siRNA's which have been modified by the addition of a 2 -0- guanidinopropyl (GP) modified nucleoside. In particular the invention relates to modified siRNAs which are capable of silencing target sequences, methods of treating and preventing infection by using the siRNAs, medicaments containing the siRNAs and use of the siRNAs.
