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Pyrimidooxazocin derivatives as mTOR inhibitors
专利权人:
SANOFI
发明人:
BRAUN, Alain,CRESPIN, Olivier,FORICHER, Yann,MARCINIAK, Gilbert,MUZET, Nicolas,NICOLAI, Eric,PASCAL, Cécile,VIVET, Bertrand,VIVIANI, Fabrice
申请号:
ES13712331
公开号:
ES2617880T3
申请日:
2013.01.25
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compound corresponding to formula (I): ** Formula ** in which: - each of the radicals R1 independently represents a (C1-C6) alkyl group, it being understood that two R1 groups carrying two different carbon atoms of the Morpholinyl ring may be linked together to form, with the morpholinyl ring, a bicyclic heterocyclic structure, - R2 and R3 independently represent: - H, or - a (C1-C6) alkyl group, - R4 represents: - H, - a (C1-C6) alkyl group, optionally substituted with a hydroxyl group, - a (C1-C6) alkoxy group, - a -L1-R10 group, in which: - L1 represents a (C1-C6) alkylene group , - R10 represents a group selected from -COOR11, -CO-R12, -OR13, -CONR14R15 and a heterocycle of 5 or 6 atoms optionally substituted with a group -R16, -COOR17, -CO-R18, -OR19 or -NR20R21 , or - a heterocycle of 5 or 6 atoms optionally substituted with a group -R22, -COOR23, -CO-R24, -OR25 or -CONR26R27, - G1 represents a divalent phenyl or heteroaryl radical of 5 to 6 atoms, optionally substituted with 1 to 4 R5 groups independently selected from a halogen atom, a -OR30 group and a (C1-C6) alkyl group - optionally substituted with a hydroxyl, - X1 represents a group -O- or -NR40-, - X2 represents a single bond or a group -CONR50-, -CONR51-O-, -COO-, -CO- or -SO2-, - R6 represents: - H, - a group - L2-R7, in which: - -L2- represents a (C1-C6) alkylene or cycloalkylene (C3-C6) group, - R7 represents a group selected from: - H, - OR60, - a halogen atom, - a halogenoalkyl (C1-C6) group, - a heterocycle of 5 to 6 atoms optionally substituted with one or more groups selected from a (C1-C6) alkyl group, a (C1-C6) alkoxy group and a group>; = O, or - a group -G2-X3-G3, in which: - X3 represents a single bond or a group -O-, -CO- or -CH2-, - G2 represents a single bond or a divalent cyclic radical of 5 a 6 atoms optionally substituted with one or more R80 groups, - G3 represents a ring of 4 to 8 atoms optionally substituted with one or more groups R81, - or -G2-X3-G3 together form a condensed
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