UEhLCh Denni S. (US),УЭЛЧ Денни С. (US),AKRITOPOULOU-ZANZE Irini (US),АКРИТОПОУЛОУ-ЗАНЗЕ Ирини (US),BRAJE Vil'frid (DE),БРАЙЕ Вильфрид (DE),D'JuRIK Stiven V (US),ДЬЮРИК Стивен В (US),UILSON Noehl' S.,UEHLCH DENNI S.,УЭЛЧ Денни С.,AKRITOPOULOU-ZANZE IRINI,АКРИТОПОУЛОУ-ЗАНЗЕ Ирини,BRAJE VILFRID,БРАЙЕ Вильфрид,DJURIK STIVEN V,ДЬЮРИК Стивен В,UILSON NOEHL S.,УИЛСОН Ноэль С.,TERNER SHON K,ТЕРНЕР Шон К
申请号：
RU2011152312/04
公开号：
RU0002542103C2
申请日:
2010.05.20
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: in general formula , fragment A is specified in a group consisting of , or , R1, R3, R4 and R5 mean hydrogen or alkyl； each of R4a and R5a represents hydrogen； G1 represents aryl or heteroaryl, which can by unsubstituted or substituted by 1, 2, 3, 4 or 5 substitutes specified in a group consisting of alkyl, halogen, cyano, -OR1b, -S(O)R2b, -C(O)R1b, -C(O)OR1b, -OC(O)N(Rb)(R3b), -(CR4bR5b)m-OR1b, -C(OH)[(CR4bR5b)m-R4b]2, and halogenalkyl； G2 means cycloalkyl, cycloalkenyl or heterocycle unsubstituted or substituted by 1, 2, 3, 4 or 5 substitutes specified in a group consisting of alkyl； Rb represents hydrogen or alkyl； R1b and R3b represents hydrogen, alkyl or halogenalkyl； R2b represents alkyl； R4b and R5b represents hydrogen, halogen, alkyl or halogenalkyl； m represents 1, 2, 3, 4 or 5； R2 is specified in a group consisting of hydrogen, alkyl, -(CR4aR5a)m-G1 and -S(O)2R6, R6 represents G1, X1 means N or CR9； X2 means N or CR10； X3 means CR11； X4 means N or CR12； provided one fragment of X1, X2 or X4 can represent N； each of R9, R10, R11, R12, R13 and R14 independently represents hydrogen, alkyl, alkenyl, halogen, -G1, -G2, -OR1a, -C(O)G3, -C(O)OR1a, -C(O)N(Rb)(R3a), -N(Rb)(R3a), -(CR4aR5a)m-G1, -CR4a=CR5a-G1, -(CR4aR5a)m-G2, -CR6a=C(R7a)2, halogenalkyl and fragment ； R1a and R3a represents hydrogen, alkyl, haloalkyl, G1, -(CR4aR5a)m-G1, G2 or -(CR4aR5a)m-G2； R6a is alkyl or halogenalkyl； R7a represents hydrogen, alkyl or helogenalkyl； G3 represents heterocycle attached to an adjoining carbonyl fragment through a nitrogen atom being a part of heterocycle； or R10 and R11 or R13 and R14 together with carbon atoms which they are attached to, form unsubstituted phenyl or cycloalkyl； Y1 means NR17, CR18R19, C(O), S(O)n or O； Y2 means NR20, CR18R19 or C(O)； Y3 means NR17, CR18R19 or C(O)； or Y1 and Y2 together represent CR18=CR19, n means 2； R17 represents hydrogen； R18 and R19 represents hydrogen； and R20 is specified in a group
