The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1)wherein R1is phenyl or the like； A is lower alkylene； Ring X is optionally substituted arylene； E is bond or lower alkenylene； Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group [wherein said heterocycloalkylene optionally contains another hetero atom]； G is -NH-G2-, -N(lower alkyl)-G2-, -NH-CH2-G2-, -N(lower alkyl)-CH2-G2- or -CH2-G2-, [wherein G2binds to R2, G2-R2is bond-R2, phenylene-G3-R2, phenylene-G4-O-R2, phenylene-G5-NH-R2, phenylene-G6-N(lower alkyl)-R2or quinolinediyl-O-R2, the phenylene of said phenylene-cotnaining groups being optionally substituted with one or more substituents； G3-R2is -O-lower alkylene-R2or the like； G4-O- is lower alkylene-O- or the like； G5is lower alkylene； G6is lower alkylene]； and R2is aryl or the like.本發明係提供具有優秀抗腫瘤效果的新穎化合物。本發明之化合物係如下列通式(1)所示其中，R1示苯基或類似基團；A示低級伸烷基；環X示任意經取代的伸芳基；E示鍵或低級的伸烯基；環Y示含有一或多個氮原子之任意經取代的伸雜環烷基，氮原子中有一者係連結至相鄰的羰基團上[其中該伸雜環烷基任意含有其他的雜原子]；G示-NH-G2-：-N(低級烷基)-G2-、-NH-CH2-G2-、-N(低級烷基)-CH2-G2-或-CH2-G2-，[其中，G2連結至R2，G2-R2示鍵-R2、伸苯基-G3-R2、伸苯基-G4-O-R2、伸苯基-G5-NH-R2、伸苯基-G6-N(低級烷基)-R2或喹啉二基-O-R2，前述含伸苯基之基團的伸苯基任意經一或多個取代基所取代；G3-R2示-O-低級伸烷基-R2或類似基團；G4-O-示低級伸烷基-O-或類似基團；G5示低級伸烷基；G6示低級伸烷基]；且R2示芳基或類似基團。
