DZhADD Ehndrju S. (US),ДЖАДД Эндрю С. (US),MUL'KhERN Meht'ju M. (US),МУЛЬХЕРН Мэтью М. (US),IJENGAR Radzhesh R. (US),ИЙЕНГАР Раджеш Р. (US),KIM Filip R. (US),КИМ Филип Р. (US),SAUEhRS Ehndrju Dzh. (US,DZHADD EHNDRJU S.,ДЖАДД Эндрю С.,MULKHERN MEHTJU M.,МУЛЬХЕРН Мэтью М.,IJENGAR RADZHESH R.,ИЙЕНГАР Раджеш Р.,KIM FILIP R.,КИМ Филип Р.,SAUEHRS EHNDRJU DZH.,САУЭРС Эндрю Дж.
申请号：
RU2009144113/04
公开号：
RU0002497816C2
申请日:
2008.04.30
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to a compound of formula or a pharmaceutically acceptable salt thereof, wherein G1 is phenyl or pyridyl, each of which is optionally additionally substituted by one substitute presented by T； G2 is phenyl, 1,3-thiazolyl or 1,3-oxazolyl, wherein G2 is bound to G1 in the para position in relation to a place of attachment of G1 to group NH in formula (I), wherein G2 means phenyl, G3 is bound to G2 in the para position of G2 in relation to G1, and wherein provided G2 represents 1,3-thiazolyl or 1,3-oxazolyl, G2 is bound to G1 in the position of 5 G2 and G3 is bound to G2 in the position of 2 G2； T in each case is independently specified in a group containing C1-6alkyl and halogen； G3 is presented by formula or by formula ； W1 is -C(R3)(R4)-C(R3)(R4)-, and W2 represents N； or W3 represents O； W4 is -C(R3)(R4) -； each R3 and R4 is hydrogen； each R5 and R6 kis hydrogen； Rc and Rd together with a carbon atom whereto attached, are a 4-5-member cycloalkyl or monocyclic heterocycle of formula ； wherein one hydrogen atoms attached to the carbon atom of the cycloalkyl ring and monocyclic heterocycle is optionally substituted by a radical specified in a group -C(O)O(R8)； W5 is -CH2- or -CH2-CH2-； W6 is O or N(RX), wherein Rx is hydrogen, C1-6alkyl or -C(O)O(Rz)； RZ in each case is independently C1-6alkyl； R8 is hydrogen； L1 is O； and X is hydrogen, C1-6alkyl, or - (CRgRh)u-C(O)O(R10)； or L1 is -CH2- and X is -C(O)OH； R10 is hydrogen； or Q is G4 or Y1-Y3； or Q is described for formula wherein Z is phenyl； G4 is benzothiazole or benzoxazole optionally additionally substituted by 1 or 2 substitutes specified in a group consisting of C1-6alkyl, halogen and -OR1； Y1 in each case is independently -C(O)-, -C(O)O- or -C(O)N(Rw)-, wherein the right side -C(O)O- and -C(O)N(Rw)- of the groups is attached to Y3 or (CRJRk)v, Y3 in each case is independently phenyl, benzyl, piperidinyl or bicyclo[4.2.0]octa-1,3,5-triene, wherein the
