MJALLI, Adnan M.M.,POLISETTI, Dharma Rao,YOKUM, Thomas Scott,SANTHOSH, Kalpathy,GUZEL, Mustafa,BEHME, Christopher,DAVIS, Stephen Thomas
申请号：
ES09718287
公开号：
ES2567451T3
申请日:
2009.03.06
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula (I): ** Formula ** wherein R is - (CH2) p-G1-L1-G2, where L1 is selected from the group consisting of: a direct bond, -CH2-, -O -, -N (R16) -, -C (O) -, -CON (R16) -, - N (R16) C (O) -, -N (R16) SO2-, -SO2N (R16) -, - C (O) -O-, -OC (O) -, -S-, -S (O) -, -S (O) 2-, and -CC-, where R16 is selected from the group consisting of: -hydrogen, -alkyl, -aryl, -alkylene-aryl； G1 is selected from the group consisting of: alkynylene, arylene, heteroarylene, fused arylcycloalkylene, fused cycloalkylarylene, fused cycloalkyl heteroarylene, fused heterocyclylarylene and fused heterocyclylheteroarylene, where G1 is optionally substituted 1-4 times with independently selected substituents of R10, wherein R10 is Rb, G2 is selected from the group consisting of: - aryl, - heteroaryl -, fused arylcycloalkyl, - fused cycloalkylaryl, - fused cycloalkyl heteroaryl, - fused heterocyclylaryl and - fused heterocyclyl heteroaryl, where G2 is optionally substituted 1-4 times with substituents independently selected from R11, where R11 is Rb, R1 is selected from the group consisting of: -CO2H, -CO2R12, where R12 is selected from the group consisting of: -C1-10 alkyl, -cycloalkyl and -aryl, wherein R12 is optionally substituted 1-4 times with a group independently selected from Rc； R2 is selected from the group consisting of: -hydrogen, -alkyl, -phenyl, -cycloalkyl, -alkylene-cycloalkyl, and - alkylene-phenyl, wherein the alkyl, phenyl and cycloalkyl groups are optionally substituted 1-4 times with a group selected independently of Rc； R3 is selected from Ra； R4 is selected from Ra； and R5 is -G3-L2-Q2-L3-G4, where L2 and L3 are independently selected from the group consisting of: a direct link, -CH2-, -O-, -N (R26) -, - C ( O) -, -CON (R26) -, -N (R26) C (O) -, -N (R26) CON (R27) -, -N (R26) C (O) O-, -OC (O) N (R26) -, -N (R26) SO2-, -SO2N (R26) -, -C (O) -O-, -OC (O) -, -S-, -S (O) -, -S (O) 2-, and -N (R26) SO2N (R27) -, wherein R26 and R27 are independently selected fr
