MITCHELL, Michael L.,ROETHLE, Paul A.,XU, Lianhong,YANG, Hong,MCFADDEN, Ryan,BABAOGLU, Kerim
申请号：
ES12719182
公开号：
ES2615734T3
申请日:
2012.04.20
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula I: ** Formula ** where: G1 is S, G2 is N, the trace link connected to G1 is a single link, the trace link connected to G2 is a double link, and the connected wavy link to R5 is a simple link； or G1 is N, G2 is S, the dashed link connected to G1 is a double bond, the dashed link connected to G2 is a single link, and the wavy link connected to R5 is a single link； or G1 is S, G2 is NR6, the dashed link connected to G1 is a single link, the dashed link connected to G2 is a single link, the wavy link connected to R5 is a double bond and R5 is oxygen； R1 is H or halo； R2 is halo, H or -CH3； R3 is -O (C1-C6) alkyl； R3 'is H； R4 is selected from aryl, heterocycle and heteroaryl, wherein any aryl, heterocycle and heteroaryl of R4 is optionally substituted with one or more groups each independently selected from halo, (C1-C6) alkyl, (C2-C6) alkenyl, (C1-C6) haloalkyl, (C3-C7) cycloalkyl, - (C1-C6) alkyl (C3-C7) cycloalkyl, -OH, - O (C1-C6) alkyl, -SH, -S (C1-C6) alkyl, -NH2, -NH (C1-C6) alkyl and -N ((C1-C6) alkyl) 2, in which (C1-C6) alkyl is optionally substituted with hydroxy, -O (C1-C6) alkyl, cyano or oxo； R5 is R5a or R5b； R6 is R6a or R6b； R5a is selected from: a) halo； b) R11, -C (>； = O) -R11, -C (>； = O) -O-R11, -O-R11, -S-R11, -S (O) -R11, -SO2 -R11, - (C1-C6) alkyl-R11, - (C1-C6) alkyl C (>； = O) -R11, - (C1-C6) alkyl-C (>； = O) -O-R11, - (C1-C6) alkyl-O-R11- (C1-C6) alkyl-SR11, - (C1-C6) alkyl-S (O) - R11 and - (C1-C6) alkyl-SO2 -R11 where each R11 is independently selected from H, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C1-C6) haloalkyl, (C3-C7) carbocycle, aryl, heterocycle and heteroaryl, in which aryl, heterocycle and heteroaryl are each optionally substituted with one or more Z11 Groups； and c) -N (R9) R10, -C (>； = O) -N (R9) R10, -OC (>； = O) -N (R9) R10, -SO2 -N (R9) R10, - (C1- C6) alkyl-N (R9) R10, - (C1- C6) alkyl-C (>； = O) -N (R9) R10, - (C1-C6) alkylOC (>； = O) -N (R9) R10, and - (C1-C6) alkyl-SO2 -N
