PROBLEM TO BE SOLVED: To provide a metalloproteinase inhibitor important to a process of plethoric physiological illness including restructuring of tissue such as growth of a fetus and bone formation.SOLUTION: A compound having a basic skeleton useful as the metalloproteinase inhibitor is represented by formula IIa, wherein G1 indicates a carbocycle or heterocycle having seven or less ring atoms G2 indicates a six-membered ring having nitrogen B indicates a direct bond, O, (1-6C) alkylene, (1-6C) heteroalkylene, CO, NHCO, CONH, NH, S or (2-6C) alkynylene and Z indicates SO2 or SO.COPYRIGHT: (C)2010,JPO&INPIT【課題】胎児の発育、骨形成のような組織の再構成を含む、多血性の生理学的疾病過程に重要、メタロプロテイナーゼ阻害剤を提供。【解決手段】メタロプロテイナーゼ阻害剤として有用な下記基本骨格を有する化合物。[式中、G1は7個以下の環原子を含む炭素環、複素環、G2は窒素を含む6員環、Bは、直接結合、O、(C1-6)アルキレン、(C1-6)ヘテロアルキレン、CO、NHCO、CONH、NH、Sおよび(C2-6)アルキニレン、ZはSO2またはSOである]【選択図】なし
