SCANIO, MARC J.,SHI, LEI,BUNNELLE, WILLIAM,SCHRIMPF, MICHAEL
申请号：
ES08732554
公开号：
ES2378116T3
申请日:
2008.03.20
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of formula (I) in which Y1 is or A is aryl, heteroaryl, heterocycle, cycloalkyl, cycloalkenyl, arylalkyl, heteroarylalkyl, heterocycloalkyl, cycloalkylalkyl, or cycloalkenyl alkyl in which each of the aryl, heteroaryl, heterocycle, cycloalkyl, cycloalkyl, , the aryl aryl alkyl moiety, the heteroaryl moiety of the heteroarylalkyl, the heterocycle moiety of the heterocycloalkyl, the cycloalkyl moiety of the cycloalkylalkyl, and the cycloalkenyl moiety of the cycloalkenyl alkyl is independently unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents, in which optional substituents are selected from the group consisting of alkyl, alkenyl, alkynyl, halogen, cyano, oxo, methylenedioxy, ethylenedioxy, -G1, -NO2, -OR1a, -OC (O) R1a, -OC (O) N (Rb) (R3a), -SR1a, -S (O) 2R2a, S (O) 2N (Rb) (R3a), -C (O) Ra, -C (O) OR1a, -C (O) N (Rb) (R3a), -N (Rb) (R3a), -N (Ra) C (O) R1a, -N (Ra) S (O) 2R2a, N (Ra) C (O) O (R1a) , -N (Ra) C (O) N ( Rb) (R3a), - (CR4aR5a) m-NO2, - (CR4aR5a) m-OR1a, - (CR4aR5a) m-OC (O) R1a, (CR4aR5a) m-OC (O) N (Rb) (R3a) , - (CR4aR5a) m-SR1a, - (CR4aR5a) mS (O) 2R2a, - (CR4aR5a) mS (O) 2N (Rb) (R3a), (CR4aR5a) mC (O) R1a, - (CR4aR5a) mC ( O) OR1a, - (CR4aR5a) mC (O) N (Rb) (R3a), - (CR4aR5a) mN (Rb) (R3a), (CR4aR5a) mN (Ra) C (O) R1a, - (CR4aR5a) mN (Ra) S (O) 2R2a, - (CR4aR5a) mN (Ra) C (O) O (R1a), - (CR4aR5a) mN (Ra) C (O) N (Rb) (R3a), - (CR4aR5a) m-G1, cyanoalkyl and haloalkyl； wherein each of R1a and R3a, in each case, is independently hydrogen, alkyl, haloalkyl, G1, or - (CR6R7) n-G1； R2a, in each case, is independently alkyl, haloalkyl, G1, or - (CR6R7) n-G1； each of R4a, R5a, R6, and R7, in each case, is independently hydrogen, halogen, alkyl, or haloalkyl； each of Ra and Rb, in each case, is independently hydrogen, alkyl, or haloalkyl； each of m and n, in each case, is independently 1, 2, 3, 4 or 5； G1 is aryl, heteroaryl, heterocycle, cycloalkyl, or cycloalkenyl, in which each G1 is independently unsubstituted or substituted wit
