ХИГГИНБОТТОМ Майкл (GB),СИМПСОН Айан (GB),ХОРТОН Джеймс (GB),ТИЗАК Чарлз (GB),ХОРГАН Энн Вьет-Анх (GB)
申请号：
RU2010148900/04
公开号：
RU2010148900A
申请日:
2009.06.04
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. The compound of formula (I) !! or its pharmaceutically acceptable salt, solvate, hydrate, geometric isomer, tautomer or optical isomer, where! each R1 is independently selected from C1-4 alkyl, C1-4 alkoxy, halogen, cyano, and CF3； ! R2 is C1-6 alkyl (optionally substituted with one or more substituents selected from hydroxy, halogen and cyano) or - [C (R4A) (R4B)] m-R5； ! R3 is hydrogen, C1-4 alkyl or fluoro-C1-4 alkyl； ! each of R4A and R4B is independently selected from hydrogen, halogen, hydroxy, C1-4 alkyl, fluoro-C1-4 alkyl, and hydroxy-C1-4 alkyl； ! R5 is C3-8cycloalkyl, C6-10aryl, heterocyclyl or heteroaryl, each of which is optionally substituted with one or more substituents selected from hydroxy, halogen, cyano, nitro, CF3 and C1-4 alkyl； ! m is 0, 1 or 2； and! n is 0, 1, 2, 3 or 4； ! provided that the compound is not selected from:! - pyridin-4-ylmethyl-bis (2-chloroethyl) carbamate； ! - (2,6-dichloropyridin-4-yl) methyldimethylcarbamate； ! - (2,6-dichloropyridin-4-ylmethylpropylcarbamate；! - pyridin-4-ylmethylmethylcarbamate；! - pyridin-4-ylmethylisopropylcarbamate；! - Pyridin-4-ylmethyl- [3- (trifluoromethyl) phenyl] carbamate；! 4-ylmethyl- (5-chloro-2-methoxyphenyl) carbamate；! - pyridin-4-ylmethyl- (2-methoxyphenyl) carbamate；! - pyridin-4-ylmethyl- (2,6-dimethylphenyl) carbamate；! - pyridine -4-ylmethyl- (2,4,6-trimethylphenyl) carbamate；! - pyridin-4-ylmethyl- (5-chloro-2,4-dimethoxyphenyl) carbamate；! - pyridin-4-ylmethyl- (2-methyl- 5-nitrophenyl) carbamate；! - pyridin-4-ylmethyl- (3-ethylphenyl) carbamate；! - pyridin-4-ylmethyl- (2,4-di etilfenil) carbamate； - pyridin-4-ilmetil- (3,4,5-trimethoxyphenyl) carbamate； - pyridin-4-ylmethyl (methyl) carbamate； - pyridin-4-ylmethylpyridine-3-ylcarbamate；1. Соединение формулы (I) !! или его фармацевтически приемлемые соль, сольват, гидрат, геометрический изомер, таутомер или оптический изомер, где ! каждый R1 независимо выбран из С1-4алкила, С1-4алкокси, галогена, циано и CF3； ! R2 представляет со
