NOBLE, Steward A.,OSHIRO, Guy,MALECHA, James W.,ZHAO, Cunxiang,ROBINSON, Carmen K.M.,DURON, Sergio G.,SERTIC, Michael,LINDSTROM, Andrew,SHIAU, Andrew,BAYNE, Christopher,KAHRAMAN, Mehmet,LOU, Boliang,G
申请号：
ES05851253
公开号：
ES2682282T3
申请日:
2005.10.25
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound having the structural formula (I) ** formula ** or a salt thereof, in which； A is a saturated or unsaturated hydrocarbon chain having 3 atoms, which form a five-member ring； T is selected from the group consisting of -C (O) OH, -C (O) NH2 and tetrazole； G1 is - (CR1R2) n-； Z is O, S or NR； n is 0 or 1； r and s are independently 0 or 1； R1 and R2 are independently selected from the group consisting of hydrogen, halogen, C1-6 alkyl, C1-6 heteroalkyl, C1-6 alkoxy and C1-6 perhaloalkyl or together they can form a cycloalkyl； X1, X2 and X3 are independently selected from the group consisting of hydrogen, C1-6 alkyl, cycloalkyl, halogen, perhaloalkyl, hydroxy, C1-6 alkoxy, nitro, cyano and NH2； G2 has the structure: ** Formula ** Y1 and Y2 are independently selected from the group consisting of N and C-X6； p is 1, 2 or 3； W is selected from the group consisting of -CX4X5- and N-X7； X4 and X5 are independently selected from the group consisting of hydrogen, C1-6 alkyl, halogen, C1-6 perhaloalkyl, hydroxy, C1-6 alkoxy, nitro, cyano, NH2 and CO2R； R is selected from the group consisting of C1-6 alkyl and hydrogen； X6 is selected from the group consisting of hydrogen, alkyl, hydroxy, alkoxy, cyano, halogen, C1-6 perhaloalkyl and NH2, or null when it forms a double bond with an adjacent ring atom； X7 is selected from the group consisting of hydrogen, alkyl, hydroxy, and C1-6 perhaloalkyl, or null when it forms a double bond with Y2； G3 is selected from the group consisting of a bond, a double bond, - (CR3R4) m-, carbonyl and - (CR3R4) mCR3>； = CR4-； m is 0, 1 or 2； R3 and R4 are independently selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 alkoxy, aryl, C1-6 perhaloalkyl, cyano and nitro； G4 is selected from the group consisting of hydrogen, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted cycloheteroalkyl, optionally substituted cycloheteroaryl are optionally individually or
