BENSON, GREGORY MARTIN,BLEICHER, KONRAD,GRETHER, UWE,KUHN, BERND,RICHTER, HANS,TAYLOR, SVEN
申请号：
ES09783005
公开号：
ES2446593T3
申请日:
2009.09.15
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compounds of the formula in which R 1 is a ring chosen from the group consisting of phenyl, naphthyl and heteroaryl, said ring is unsubstituted or substituted by 1-3 substituents independently selected from the group consisting of lower alkyl, halogen, lower halogenoalkyl, hydroxy, lower alkoxy, lower halogenoalkoxy and cyano； R2, R3, R4 and R5 independently of each other are chosen from the group consisting of hydrogen, halogen or lower alkyl； R2 'and R3' together and also R4 'and R5' together are replaced by a double bond, or R2 ', R3', R4 'and R5' are hydrogen； R6 is chosen from the group consisting of hydrogen, methyl, ethyl, hydroxy, methoxy, fluorine, fluoromethyl, difluoromethyl and trifluoromethyl； R7 is selected from the group consisting of lower alkyl, cycloalkyl, lower cycloalkylalkyl, lower alkoxyalkyl, unsubstituted phenyl or phenyl substituted by 1-3 substituents independently selected from the group consisting of lower alkyl, halogen, lower halogenoalkyl, hydroxy, lower alkoxy, lower halogenalkoxy and cyano, lower phenylalkyl, in which the phenyl is unsubstituted or substituted by 1-3 substituents chosen independently from the group consisting of lower alkyl, halogen, lower halogenoalkyl, hydroxy, lower alkoxy, lower halogenoalkoxy and cyano, unsubstituted heteroaryl or heteroaryl substituted by 1-3 substituents independently selected from the group consisting of lower alkyl, halogen, lower halogenoalkyl, hydroxy, lower alkoxy, lower halogenoalkoxy and cyano, and heterocyclyl； and R8 is selected from the group consisting of -C (O) -NH-R9, -CR11R12-OR10, -O- (CR11R12) n-R10； -CR11R12-SR10, -CR11R12-SO2-R10, -CR11R12-NR13-R10； -CH>； = CH-R10 and - (CH2) p-R10, where n is the number 0 or 1, p is the number 2, R9 is chosen from the group consisting of lower alkyl, cycloalkyl, lower cycloalkylalkyl, cycloalkyl substituted by 1-3 substituents independently selected from the group consisting of hydroxy, carboxyl, tetrazolyl, lower carboxy alkyl, (lower alk
