WISEMAN, John,WILSON, Lawrence,LIOTTA, Dennis C,NATCHUS, Michael G.
申请号：
ES11844404
公开号：
ES2607604T3
申请日:
2011.12.02
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound comprising formula IB, ** Formula ** or a salt thereof, in which R1 is hydrogen, R2 and R3 together with the atoms to which they are attached to form a carbocyclyl or heterocyclyl, in which the carbocyclyl or heterocyclyl are optionally substituted with one or more, the same or different, of R10； R4 is hydrogen, alkyl, halogen, cyano, hydroxy, amino, mercapto, formyl, carboxy, carbamoyl, alkoxy, alkylthio, alkylamino, aminoalkyl, (alkyl) 2amino, alkylsulfinyl, alkylsulfonyl, arylsulfonyl, carbocyclyl, aryl or heterocyclyl, in which R4 is optionally substituted with one or more, the same or different, from R10； R5, R6 and R7 are each individually and independently hydrogen, halogen, nitro, cyano, hydroxy, trifluoromethoxy, trifluoromethyl, amino, formyl, carboxy, carbamoyl, mercapto, sulphamoyl, methyl, ethyl, methoxy, ethoxy, acetyl, acetoxy , methylamino, ethylamino, dimethylamino, diethylamino, N-methyl-N-ethylamino, acetylamino, Nmethylcarbamoyl, N-ethylcarbamoyl, N, N-dimethylcarbamoyl, N, N-diethylcarbamoyl, N-methyl-N-ethylcarbamoyl, methylthio, , ethylsulfinyl, mesyl, ethylsulfonyl, methoxycarbonyl, ethoxycarbonyl, N-methisulfamoyl, Nethylsulfamoyl, N, N-dimethylsulfamoyl, N, N-diethylsulfamoyl, N-methyl-N-ethylsulfamoyl, carbocyclyl, aryl or heteroyl； R10 is alkyl, halogen, nitro, cyano, hydroxy, amino, mercapto, formyl, carboxy, carbamoyl, alkoxy, alkylthio, alkylamino, (alkyl) 2amino, alkylsulfinyl, alkylsulfonyl, arylsulfonyl, carbocyclyl, aryl or heterocyclyl, in which R10 is optionally substituted with one or more, the same or different, of R11； R11 is alkyl, halogen, nitro, cyano, hydroxy, amino, mercapto, formyl, carboxy, carbamoyl, alkoxy, alkylthio, alkylamino, (alkyl) 2amino, alkylsulfinyl, alkylsulfonyl, arylsulfonyl, carbocyclyl, aryl or heterocyclyl, in which R11 is optionally substituted with one or more, the same or different, of R12； and R12 is halogen, nitro, cyano, hydroxy, trifluoromethoxy, trifluoromethyl, amino, formyl, carbox
