Ralf Plate;Christiaan Gerardus Johannes Maria Jans
发明人:
Ralf Plate,Christiaan Gerardus Johannes Maria Jans
申请号：
US12065241
公开号：
US08575152B2
申请日:
2006.08.25
申请国别(地区):
US
年份:
2013
代理人:
摘要：
This invention relates to novel amino acid derivatives of formula (I) wherein the R groups have the following meanings: —R1 is —H or —(1-4C)alkyl； —R2 is —C(O)R15 or —S(O)2R15； —R3 is —H, —(1-4C)alkyl or —OR16； —R4 is —H, —(1-4C)alkyl or —OR16； —R6 is —H or —C(R16)NOR16； —R7 is —H, -halogen, -cyano； —(1-6C)alkyl, —(2-6C)alkenyl or —(2-6C)alkynyl, all optionally substituted with -amino, -hydroxyl or -halogen； —R8 is —H, -cyano, -halogen, -nitro； —(1-6C)alkyl, —(2-6C)alkenyl, —(2-6C)alkynyl or —O(1-6C)alkyl, all optionally substituted with -amino, -hydroxyl or -halogen； -(hetero)aryl, optionally substituted with -cyano, -halogen, —(1-4C)alkyl, —(1-4C)alkoxy, —(1-4C)alkoxy(1-4C)alkyl or -(hetero)aryl； —C(R16)NOR16； —C(O)N(R17)2； —C(O)R18, —C(O)OR19, —NHC(O)R20, or —NHS(O)2R21； —R9 is —H, -halogen, -cyano, or —(1-4C)alkyl, optionally substituted with -halogen； —R10 is —H or —(1-4C)alkyl； —R11 is —H； —R12 is —H, -cyano or —(1-4C)alkyl； —R13 is —H, —(1-4C)alkyl, -halogen or -formyl； —R14 is —H, -halogen, -cyano, —(1-4C)alkyl or -(hetero)aryl； or a pharmaceutically acceptable salt thereof. The compounds of this invention are highly specific for the glucocorticoid receptor and may be used for treating inflammatory diseases.
