BIRD Richard L. (US),БИРД Ричард Л. (US),VILUGONDA Vidyasagar (US),ВИЛУГОНДА Видьясагар (US),VU Tong (US),ВУ Тонг (US),DONELLO Dzhon E. (US),ДОНЕЛЛО Джон Е. (US),VISVANAT Veena (US),ВИСВАНАТ Веена (US,BIRD Richard L.,БИРД Ричард Л.,VILUGONDA Vidyasagar,ВИЛУГОНДА Видьясагар,VU Tong,ВУ Тонг,DONELLO Dzhon E.,ДОНЕЛЛО Джон Е.,VISVANAT Veena,ВИСВАНАТ Веена,GARST Majkl E.,ГАРСТ Майкл Е.
申请号：
RU2014122753
公开号：
RU0002645673C2
申请日:
2012.11.10
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to organic chemistry, namely to 2,5-dioxoimidazolidin-1-yl-3-phenylurea derivative of formula (I) or its enantiomer, diastereomer or pharmaceutically acceptable salt, where R1 is halogen or hydrogen； R2 is halogen, C1-8 alkyl, OR9, CN or SR15； R3 is hydrogen or C6-10 aryl； R4 is C1-8 alkyl,, , , , ,C3-8 cycloalkyl or together with R5 forms a spiro-monocyclic or bicyclic carbocyclic saturated or partially unsaturated 5- to 10-membered ring； R5 is C1-8 alkyl optionally substituted with phenyl which is optionally substituted Cl, F, OH, F and OH, -(COOMe) or -COOH； furan, methylfuran, thiophene, pyridine, indole or OH； C3-8 cycloalkyl, ethylindole or together with R4 forms a spiro-monocyclic or bicyclic carbocyclic saturated or partially unsaturated 5- to 10-membered ring； R6 is halogen or hydrogen； R7 is hydrogen； R8 is halogen or hydrogen； R9 is C1-8 alkyl； R15 is C1-8 alkyl； R17 is hydrogen, C6-10 aryl or C1-8 alkyl optionally substituted with methoxyphenyl； R18 is hydrogen or C1-8 alkyl substituted OH, CO2t-Bu, COOH or CONH2； R19 is C1-8 alkyl substituted with OH； each R20 is independently selected from hydrogen or C1-8 alkyl； R21 is hydrogen； n is 1 or 2； m is 1 or 2； and including the following compounds:and；with the proviso that the compound of formula I does not have the structure indicated in claim 1. Invention also relates to pharmaceutical composition based on the compound of formula I. .EFFECT: new 2,5-dioxoimidazolidine-1-yl-3-phenylurea derivatives useful as modulators of N-formylpeptide receptor 1 (FPRL-1) have been obtained.12 cl, 11 tbl, 17 exИзобретение относится к области органической химии, а именно к производному 2,5-диоксоимидазолидин-1-ил-3-фенилмочевины формулы (I) или к его энантиомеру, диастереомеру или фармацевтически приемлемой соли, где R1 представляет собой галоген или водород； R2 представляет собой галоген, С1-8 алкил, OR9, CN или SR15； R3 представляет собой водород или С6-10 арил； R4 представл
