GALLEY, Guido,GOERGLER, Annick,GROEBKE ZBINDEN, Katrin,NORCROSS, Roger
申请号：
ES09780600
公开号：
ES2556633T3
申请日:
2009.07.15
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound (4S) -4- (4,4,4-trifluoro-3-phenyl-butyl) -4,5-dihydro-oxazol-2-ylamine (4S) -4- (3-phenyl-butyl) -4 , 5-dihydro-oxazol-2-ylamine (4S) -4- (3-phenyl-pentyl) -4,5-dihydro-oxazol-2-ylamine (4S) -4- [3- (4-fluoro-phenyl) ) -butyl] -4,5-dihydro-oxazol-2-ylamine (4S) -4- [3- (4-fluoro-phenyl) -pentyl] -4,5-dihydro-oxazol-2-ylamine (4S) -4-methyl-4- (3-phenyl-butyl) -4,5-dihydro-oxazol-2-ylamine (4S) -4- [3- (4-chloro-phenyl) -pentyl] -4,5- dihydro-oxazol-2-ylamine (4S) -4- [3- (3-trifluoromethyl-phenyl) -pentyl] -4,5-dihydro-oxazol-2-ylamine (4S) -4- (3-m-tolyl -pentyl) -4,5-dihydro-oxazol-2-ylamine (S) -4 - [(S) -3- (4-fluoro-phenyl) -butyl] -4,5-dihydro-oxazol-2-ylamine (S) -4 - [(R) -3- (4-fluoro-phenyl) -butyl] -4,5-dihydro-oxazol-2-ylamine or (4S) -4- [3- (3,5- difluoro-phenyl) -pentyl] -4,5-dihydro-oxazol-2-ylamine encompassed by the formula ** Formula ** wherein R 1 is hydrogen, C 1-7 alkyl, C 1-7 alkoxy, substituted C 1-7 alkyl by halogen, C1-7 alkoxy substituted by halogen, cyano, nitro, hydroxy, C (O) O-C1-7 alkyl, S (O) 2-C1-7 alkyl, C ( O) OCH2-phenyl, OCH2-phenyl, tetrazol-1-yl, phenyl optionally substituted by halogen, or is phenyloxy optionally substituted by halogen, or is benzyl optionally substituted by halogen or is benzyloxy optionally substituted by halogen, in which the substituents for n>； 1 they can be the same or different； R 'is C1-7 alkyl, C1-7 alkoxy or C1-7 alkyl substituted by halogen； R2 is hydrogen or C1-7 alkyl； Y is phenyl, naphthyl, C3-6 cycloalkyl or pyridin-2-or 3-yl, pyrimidin-2-yl or quinolin-6 or 7-yl； n is 1, 2 or 3； or a pharmaceutically suitable acid addition salt.Un compuesto (4S)-4-(4,4,4-trifluoro-3-fenil-butil)-4,5-dihidro-oxazol-2-ilamina (4S)-4-(3-fenil-butil)-4,5-dihidro-oxazol-2-ilamina (4S)-4-(3-fenil-pentil)-4,5-dihidro-oxazol-2-ilamina (4S)-4-[3-(4-fluoro-fenil)-butil]-4,5-dihidro-oxazol-2-ilamina (4S)-4-[3-(4-fluoro-fenil)-pentil]-4,5-dihidro-oxazol-2-ilamina (4S)-4-metil-4-(3-fenil-butil)-4,5-dihidro-ox
