Jason Dallwig,David Hagen,Ching-Ying Cheung,Gerald Thomas,Stephen Yue
申请号：
US13902076
公开号：
US09040561B2
申请日:
2013.05.24
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Cyanine dye compounds having a substituted methine moiety that are nucleic acid stains, particularly for fluorescent staining of RNA, including compounds having the formulawhere R1 is a C1-C6 alkyl, sulfoalkyl, carboxyalkyl or C1-C6 alkoxy each R2 is independently selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, fused benzo, trifluoromethyl, amino, sulfo, carboxy and halogen, that is optionally further substituted at least one of R3, R4, and R5 is an alkyl, aryl, heteroaryl, cyclic, or heterocyclic moiety that is optionally substituted by alkyl, amino, aminoalkyl, carboxy, nitro, or halogen and the remaining R3, R4 or R5 are hydrogen X is S, O, or Se and D is a substituted or unsubstituted pyridinium, quinolinium or benzazolium moiety.
