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Arylamide derivatives as TTX-S blockers
专利权人:
RaQualia Pharma Inc
发明人:
YAMAGISHI, Tatsuya,KAWAMURA, Kiyoshi,ARANO, Yoshimasa,MORITA, Mikio
申请号:
ES11834032
公开号:
ES2613538T3
申请日:
2011.10.18
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of the following formula (II) ** Formula ** in which R1 is independently selected from the group consisting of -CF3, -CHF2, -OCF3, - OCHF2, -OCH2CHF2, -OCH2CF3, -OCF2CHF2, -OCF2CF3 , -OCH2CH2CF3, - OCH (CH3) CF3, -OCH2C (CH3) F2, -OCH2CF2CHF2, - OCH2CF2CF3, -OCH2CH2OCH2CF3, - NHCH2CF3, -SCF3, -SCH2CF3, -CH2CF3, -CH2CH2CF3 10, -CH2OCH2CF3 and - OCH2CH2OCF3; R2 is independently selected from the group consisting of: (1) hydrogen, (2) halogen, (3) hydroxyl, (4) -On-C1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R5, (5) -On C3-6 cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one or more substituents independently selected from R5, (6) - C2-4 on-alkenyl, where the alkenyl is without replace or substituted with one or more substituents independently selected from R5, (7) -On-phenyl or -On-naphthyl, where the phenyl or naphthyl is unsubstituted or substituted with one or more substituents independently selected from R5, (8) -On-heterocyclic group, where the heterocyclic group is unsubstituted or substituted with one or more substituents independently selected from R5, (9) - (C>; = O) -NR7R8, (10) -NR7R8, (11) -S ( O) 2-NR7R8, (12) -NR7- S (O) 2R8, (13) -S (O) t-R7, where t is 0, 1 or 2, (1 4) - NR7 (C>; = O) R8, (15) -CN and (16) -NO2; where n is 0 or 1, when n is 0, a chemical bond is present in the place of -On-; p is 1, 2, 3 or 4; when p is two or more than two, R2 may be the same or different; R3 and R4 are independently hydrogen or C1-6 alkyl which is unsubstituted or substituted with one or more substituents independently selected from halogen, hydroxyl and -O-C1-6 alkyl, neither R3 nor R4 are C1-6 alkyl at the same time. R5 is selected from the group consisting of: (1) hydrogen, (2) halogen, (3) hydroxyl, (4) - (C>; = O) m-Ol-C1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R6, (5) -Ol-per
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