DEWDNEY, NOLAN,LOU, YAN,SJOGREN, ERIC,SOTH, MICHAEL
申请号：
ES09780172
公开号：
ES2552681T3
申请日:
2009.07.06
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
Compound of formula I, II, III, IV or V: ** Formula ** in which: R is H, -R1, -R1-R2-R3, -R1-R3 or -R2-R3； wherein R1 is aryl, heteroaryl, cycloalkyl or heterocycloalkyl, and is optionally substituted with R1 ', in which R1' is C1-6 alkyl, hydroxy, hydroxy C1-6 alkyl, C1-6 alkoxy, halogen, nitro, amino , cycloalkyl, heterocycloalkyl, cyano or C1-6 haloalkyl, R2 is -C (>； = O), -C (>； = O) O, -C (>； = O) N (R2 '), - (CH2) qo - S (>； = O) 2； wherein R2 'is H or C1-6 alkyl； and q is 1, 2 or 3, R3 is H or R4； wherein R4 is C1-6 alkyl, C1-6 alkoxy, C1-6 heteroalkyl, aryl, arylalkyl, alkylaryl, heteroaryl, alkylheteroaryl, heteroaryl-alkyl, cycloalkyl, alkyl-cycloalkyl, cycloalkyl-alkyl, heterocycloalkyl, alkyl-heterocycloalkyl or heterocycloalkyl-alkyl, and is optionally substituted with one or more of C1-6 alkyl, hydroxy, oxo, C1-6 hydroxyalkyl, C1-6 alkoxy, halogen, nitro, amino, cyano, C1-6 alkylsulfonyl or C1- haloalkyl 6, X is CH or N, Q is a carbon or nitrogen atom, in which the carbon atom is unsubstituted or substituted by halogen, hydroxy or C1-6 alkyl, in which C1-6 alkyl is found optionally substituted with one or more substituents selected from the group consisting of hydroxy, C1-6 alkoxy, amino and halogen, each Y1 is, independently, Y1a or Y1b, wherein Y1a is halogen, Y1b is C1-6 alkyl, optionally substituted with one or more Y1b ', wherein Y1b' is hydroxy, C1-6 alkoxy or halogen, n is 0, 1, 2 or 3, Y2 is Y2a or Y2b, in which Y2a is H or halogen, Y2b is C1-6 alkyl, optionally substituted with one or more Y2b ', in which Y2b' is hydroxy, C1-6 alkoxy or halogen, Y3 is H, halogen or C1-6 alkyl, wherein C1-6 alkyl is optionally substituted with one or more substituents selected from the group consisting of hydroxy, C1-6 alkoxy , amino and halogen, m is 0 or 1； Y4 is Y4a, Y4b, Y4c or Y4d, where Y4a is H or halogen, Y4b is C1-6 alkyl, optionally substituted with one or more substituents selected from the group consisting of C1-6 haloalkyl, halogen, hydrox
