DEWDNEY, NOLAN JAMES,HAWLEY, RONALD CHARLES,KONDRU, RAMA K.,LAI, YINGJIE,LOU, YAN
申请号：
ES10714295
公开号：
ES2513915T3
申请日:
2010.04.21
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compound of formula A: in which: Z * is selected from the group consisting of: and in which: Q1 is NH or O, Q2 is N or C (Y6), R is H, -R1, -R1 -R2-R3, -R1-R3 or-R2-R3, R1 is aryl, heteroaryl, cycloalkyl or heterocycloalkyl, and is optionally substituted with one or more C1-6 alkyl, hydroxy, C1-6 hydroxyalkyl, C1-6 alkoxy, halo, nitro, amino, amido, cyano, oxo or C1-6 haloalkyl, R2 is - C (>； = O), -C (>； = O) O, -C (>； = O) NR2 ', -NHC (>； = O) O, -C (>； = NH) NR2 'or -S (>； = O) 2, R2' is H or C1-6 alkyl, R3 is H or R4, R4 is C1-6 alkyl, amino, aryl , arylalkyl, alkylaryl, heteroaryl, alkylheteroaryl, heteroarylalkyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, heterocycloalkyl, alkylheterocycloalkyl or heterocycloalkylalkyl, and optionally substituted with one or more of C1-6 alkyl, hydroxy, C1-6 alkoxy, alkoxy C1-6 alkylsulfonyl, C1-6 alkylsulfonamido, carbamate, carboxy, ester, amido, acyl, halo, nitro, amino, cyano, oxo or C1-6 haloalkyl, X is CH or N； Y1 is H, C1-6 alkyl, or C1-6 haloalkyl, Y2 is Y2a or Y2b, Y2a is H or halogen, Y2b is C1-6 alkoxy or C1-6 alkyl, optionally substituted with one or more Y2b ', Y2b' 35 is hydroxy or halogen, each Y2 'is independently Y2'a or Y2'b, Y2'a is halogen or hydroxy, Y2'b is C1-6 alkoxy or C1-6 alkyl, optionally substituted with one or more Y2'b ', Y2b' is hydroxy or halogen, p is 0, 1 or 2； Y3 is Y3a or Y3b, Y3a is halogen or hydroxy, Y3b is C1-6 alkoxy or C1-6 alkyl, optionally substituted with one or more substituents selected from the group consisting of hydroxy, C1-6 alkoxy, amino and halogen,Compuesto de fórmula A: en la que: Z* se selecciona de entre el grupo que consiste de: y en el que: Q1 es NH o O, Q2 es N o C(Y6), R es H, -R1, -R1-R2-R3, -R1-R3 o-R2-R3, R1 es arilo, heteroarilo, cicloalquilo o heterocicloalquilo, y se sustituye opcionalmente con uno o más alquilos C1-6, hidroxi, hidroxialquilos C1-6, alcoxi C1-6, halo, nitro, amino, amido, ciano, oxo o haloalquilo C1-6,R2 es - C(>；=O), -C(>；
