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Novel amino pyrimidine derivatives
专利权人:
Novartis AG
发明人:
ANGST, Daniela,GESSIER, François,VULPETTI, Anna
申请号:
ES14821285
公开号:
ES2655527T3
申请日:
2014.11.28
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of formula (I), or a pharmaceutically acceptable salt thereof ** (See formula) ** in which, R1 is hydrogen, C1-C6 alkyl optionally substituted with hydroxy; R2 is hydrogen or halogen; R3 is hydrogen or halogen; R4 is hydrogen; R5 is hydrogen or halogen; or R4 and R5 are linked together and represent a bond, -CH2-, -CH2-CH2-, - CH>; = CH-, -CH>; = CH-CH2-; -CH2- CH>; = CH-; or -CH2-CH2-CH2-; R6 and R7 can be independently of each other H, C1-C6 alkyl optionally substituted with hydroxyl, C3-C6 cycloalkyl optionally substituted with halogen or hydroxy, or halogen; R8, R9, R, R ', R10 and R11 can be independently of each other H or C1-C6 alkyl optionally substituted with C1-C6 alkoxy; or any two of R8, R9, R, R ', R10 and R11 together with the carbon atom to which they are attached can form a saturated 3-6 membered carbocyclic ring; R12 is hydrogen or C1-C6 alkyl optionally substituted with halogen or C1-C6 alkoxy; or R12 and any one of R8, R9, R, R ', R10 or R11 together with the atoms to which they are attached can form a 4, 5, 6 or 7 membered azacyclic ring, said ring may optionally be substituted with halogen , cyano, hydroxy, C1-C6 alkyl, or C1-C6 alkoxy; n is 0 or 1; and R13 is C2-C6 alkenyl optionally substituted with C1-C6 alkyl, C1-C6 alkoxy or N, N-di-C1-C6 alkylamino; C2-6 alkynyl optionally substituted with C1-C6 alkyl or C1-C6 alkoxy; or C2-C6 alkylenyl oxide optionally substituted with C1-C6 alkyl.Un compuesto de fórmula (I), o una sal farmacéuticamente aceptable del mismo **(Ver fórmula)** en el que, R1 es hidrógeno, alquilo C1-C6 opcionalmente sustituido con hidroxi; R2 es hidrógeno o halógeno; R3 es hidrógeno o halógeno; R4 es hidrógeno; R5 es hidrógeno o halógeno; o R4 y R5 están unidos entre sí y representan un enlace, -CH2-, -CH2-CH2-, - CH>;=CH-, -CH>;=CH-CH2-; -CH2- CH>;=CH-; o -CH2-CH2-CH2-; R6 y R7 pueden ser independientemente el uno del otro H, alquilo C1-C6 opcionalmente sustituido con hidroxilo, cicloalquilo C3-C6 opci
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