Isoxazol-Pyridazine Derivatives

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专利权人:

F. HOFFMANN-LA ROCHE AG

发明人:

LUCAS, MATTHEW C.,THOMAS, ANDREW

申请号：

ES10719306

公开号：

ES2467701T3

申请日:

2010.04.28

申请国别(地区):

ES

年份:

2014

代理人:

摘要：

The compounds of formula I, ** Formula ** in which R 1 is C 1-6 alkyl or C 1-6 alkyl substituted by 1-5 substituents individually selected from amino, halogen, (C 1-6 alkyl, C 1-6 alkyl) N - y (C1-6 alkyl, H) N-； R2 is H, C1-6 alkyl or C1-6 alkyl substituted by 1-5 substituents individually selected from amino, halogen, halogen C1-6 alkoxy, hydroxy, C1-6 alkoxy, (C1-6 alkyl, C1-6 alkyl) N-, (C1-6 alkyl, H) N-, nitro and C1-6- S (O) 2- alkyl； R3 is H, C1-6 alkyl or C1-6 alkyl substituted by 1-5 substituents individually selected from amino, halogen, halogen C1-6 alkoxy, hydroxy, C1-6 alkoxy, (C1-6 alkyl, C1-6 alkyl) N-, (C1-6 alkyl, H) N-, nitro and C1-6 alkyl -S (O) 2-； R4 is selected from the group consisting of i) H, ii) C1-6 alkyl, iii) C1-6 alkyl substituted by 1-5 substituents individually selected from amino, halogen, halogen C1-6 alkoxy, hydroxy, C1-6 alkoxy , (C1-6 alkyl, C1-6 alkyl) N-, (C1-6 alkyl, H) N-, nitro and C1-6-S (O) 2-, iv) heterocyclyl, and v) heterocyclyl substituted with 1 -4 substituents individually selected from amino, halogen, halogen C1-6 alkoxy, halogen C1-6 alkyl, hydroxy, C1-6 hydroxyalkyl, C1-6 alkoxy, C1-6 alkyl-alkoxy, C1-6 alkyl, (C1 alkyl -6, C1-6 alkyl) N-, (C1-6 alkyl, H) N-, nitro and C1-6-S (O) alkyl 2-； or pharmaceutically acceptable salts thereof.Los compuestos de fórmula I,**Fórmula** en los que R1 es alquilo C1-6 o alquilo C1-6 sustituido por 1-5 sustituyentes seleccionados individualmente entre amino, halógeno, (alquilo C1-6, alquilo C1-6)N- y (alquilo C1-6, H)N-； R2 es H, alquilo C1-6 o alquilo C1-6 sustituido por 1-5 sustituyentes seleccionados individualmente entre amino, halógeno, halógeno alcoxi C1-6, hidroxi, alcoxi C1-6, (alquilo C1-6, alquilo C1-6)N-, (alquilo C1-6, H)N-, nitro y alquilo C1-6- S (O)2-； R3 es H, alquilo C1-6 o alquilo C1-6 sustituido por 1-5 sustituyentes seleccionados individualmente entre amino, halógeno, halógeno alcoxi C1-6, hidroxi, alcoxi C1-6, (alquilo C1-6, alquilo C1-6)N-, (alquilo C1-6, H

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