COATES, DAVID ANDREW,DE DIOS MAGANA, ALFONSO,DE PRADO GONZALES, ANA,DEL PRADO CATALINA, MIRIAM FILADELFA,GARCIA PAREDES, MARIA CRISTINA,GELBERT, LAWRENCE MARK,KNOBELOCH, JOHN MONTE,MARTIN DE LA NAVA,
申请号：
PE0012552011
公开号：
PE01072012A1
申请日:
2009.12.15
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Pirimidinamina pyridin - refers to a compound of formula (i) wherein R1 is alkyl, cycloalkyl C3 C5, C5 or C3 - cyclopropyl Methyl R2 and R3 are H or Fluorine R4 is H or CH3 is C1 - C6 alkyl R5 or R6 and R7 are - nr6r7 C1 - C3 alkyl Q CH2 is O, S, or a direct link W e are C o n.Preferred compounds are: [5 - (4 - 1 - methyl - Ethyl piperazin) pyridin-2-yl] - 5 - fluoro - [4 - (7 - fluoro - 4 - (7 - fluoro - isopropyl - 3 - 2 - methyl - 3 - 5 - il served) - pyrimidine 2 - yl] - Amine, 5 - fluoro - [4 - (7 - fluoro - isopropyl - 3 - 2 - methyl - 3 - 5 - il served - pyrimidin-2-yl) - yl] - 2 - [5 - (1 - isopropyl - iloxi piperidin-4-yl) - pyrimidine 2 - yl] - amine[4 - (3 - 7 - 2-cyclopropyl-1 - fluoro - 2 - methyl - 5 - 3h served - il - 5 - fluoro - pyrimidin-2-yl) - yl] - 2 - [5 - (1 - Methyl ethyl piperidin-4-yl) pyridin-2-yl] - Amine, among others. It also relates to a Pharmaceutical formulation. These compounds are inhibitors of Cdk4 and Cdk6 Kinases and are useful in the treatment of diseases involving Cell Proliferation, such as cancerREFERIDA A UN COMPUESTO PIRIDIN-PIRIMIDINAMINA DE FORMULA (I), DONDE R1 ES ALQUILO C3-C5, CICLOALQUILO C3-C5 O CICLOPROPIL-METILO R2 Y R3 SON H O FLUOR R4 ES H O CH3 R5 ES ALQUILO C1-C6 O -NR6R7 R6 Y R7 SON ALQUILO C1-C3 Q ES CH2, O, S O UN ENLACE DIRECTO W E Y SON C O N. SON COMPUESTOS PREFERIDOS: [5-(4-ETIL-PIPERAZIN-1-ILMETIL)-PIRIDIN-2-IL]-[5-FLUORO-4-(7-FLUORO-4-(7-FLUORO-3-ISOPROPIL-2-METIL-3H-BENZOIMIDAZOL-5-IL)-PIRIMIDIN-2-IL]-AMINA, [5-FLUORO-4-(7-FLUORO-3-ISOPROPIL-2-METIL-3H-BENZOIMIDAZOL-5-IL)-PIRIMIDIN-2-IL]-[5-(1-ISOPROPIL-PIPERIDIN-4-ILOXI)-PIRIMIDIN-2-IL]-AMINA, [4-(3-CICLOPROPIL-7-FLUORO-2-METIL-3H-BENZOIMIDAZOL-5-IL)-5-FLUORO-PIRIMIDIN-2-IL]-[5-(1-ETIL-PIPERIDIN-4-ILMETIL)-PIRIDIN-2-IL]-AMINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA FORMULACION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE CINASAS CDK4 Y CDK6 Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES QUE IMPLICAN PROLIFERACION CELULAR TALES COMO CANCER
