COMPUESTOS DE NUCLEO IMIDAZO[1,2-a]PIRAZINA O 5,6,7,8-TETRAHIDROIMIDAZO[1,2-a]PIRAZINA SUSTITUIDOS Y COMPOSICIONES DE LOS MISMOS, UTILES EN EL TRATAMIENTO DE ENFERMEDADES PARASITICAS
CHATTERJJE, ARNAB K.,NAGLE, ADVAIT,WU, TAO,TULLY, DAVID,KUHEN, KELLI L.
申请号：
PE0000262012
公开号：
PE03992013A1
申请日:
2010.07.09
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Referring to a pyrazine Derivative of formula (IA) or (IB), (IC), where N and M is an integer from 0 to 4 ra is H, x3nr7r8, x3or8, among others RB is H and c1-c4 alkyl r1 is OR13, C (OR) OR13, among others R13 is h, alkyl of C1 - C6 C1 - C6 alkyl, Halo, among others R2 is H, c1-c6 alkyl, amino, among others H and alkyl R4 is C1 - C6 R5 C1 - C6 is H, alkyl, cycloalkyl, among others R6 is C3, C8,Aryl C6 C10, among others R7 is H or alkyl of C1 - C3 R8 is C1 - C10 alkyl, cycloalkyl C3, C8, among others R9 is H and alkyl c1-c6 alkyl is h R10 and R11 is C1 - C6 H and alkyl C1 - C6 R12 is H, alkyl C1 - C6, among others.Preferred compounds are: 2 - amino - 1 - (2 - (4-fluorophenyl) - 3 - (4 - fluorofenilamino) - 8.8 - dimethyl - 5.6 - dihidroimidazo [1,2-a] 7 (8h) - il) ethanone, 2 - amino - 1 - (3 - (3,4 - difluorofenilamino) - 2 - (4-fluorophenyl) - 5.6 - dihidroimidazo [1,2-a] 7 (8h) - yl) - 2 - metilpropan ONA - 1 -, 2 - amino - 1 - (3 - (4 - (4 - (2 - clorofenilamino) - 4-fluorophenyl) - 8.8 - dimethyl - 5.6 - dihidroimidazo [1,2-a] 7 (8h) - il) ethanone, among others.These compounds are useful in the treatment and Prevention of infections caused by Plasmodium falciparum and Plasmodium vivax Plasmodium ovale malaria, Plasmodium, Trypanosoma cruzi and Leishmania parasitesREFERIDA A UN DERIVADO DE PIRAZINA DE FORMULA (Ia), (Ib) Y (Ic), DONDE n Y m SON UN ENTERO DE 0 A 4 Ra ES H, X3NR7R8, X3OR8, ENTRE OTROS Rb ES H Y ALQUILO C1-C4 R1 ES OR13, C(O)OR13, ENTRE OTROS R13 ES H, ALQUILO C1-C6, HALO ALQUILO C1-C6, ENTRE OTROS R2 ES H, ALQUILO C1-C6, AMINO, ENTRE OTROS R4 ES H Y ALQUILO C1-C6 R5 ES H, ALQUILO C1-C6, ENTRE OTROS R6 ES CICLOALQUILO C3-C8, ARILO C6-C10, ENTRE OTROS R7 ES H O ALQUILO C1-C3 R8 ES ALQUILO C1-C10, CICLOALQUILO C3-C8, ENTRE OTROS R9 ES H Y ALQUILO C1-C6 R10 ES H Y ALQUILO C1-C6 R11 ES H Y ALQUILO C1-C6 R12 ES H, ALQUILO C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-AMINO-1-(2-(4-FLUOROFENIL)-3-(4-FLUOROFENILAMINO)-8,8-DIMETIL-5,6-DIHIDROIMIDAZO[1,2-
