NABUURS, SANDER BERNARDUS,CALS, JOSEPH MARIA GERARDUS BARBARA
申请号：
PE0007332016
公开号：
PE08912016A1
申请日:
2014.12.03
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
The present Invention relates to compounds of formula I where A11, A12, A13 and A14 are n o CR11, cr12, cr13, cr14 respectively r1 is alkyl, cycloalkyl - C1 - C6 C3, C6, among others R2 and R3 are h, F, among other alkyl R4 is H, or C1 - C6 R5 is H, hydroxyethyl, among others, R6, R7, R8, R9, R10 R11, R12, R13 and R14 are h, halogen, among others, R15 and R16 are h, alkyl of C1 - C6, among others.Preferred compounds are: N - (4 - (1,1,1,3,3,3-hexafluoro-2 - hidroxipropan - 2 - il) phenyl) - 2 - (4 - (methylsulfonyl) phenyl) acetamide 2 - (4 - (ethylsulfonyl) phenyl) - N - (4 - (1,1,1,3,3,3-hexafluoro-2 - hidroxipropan - 2 - il) phenyl) acetamide among others. It also relates to a Pharmaceutical composition.These compounds are inhibitors of ROR gamma and are useful in the treatment of autoimmune diseases and inflammatory diseasesLa presente invencion se refiere a compuestos de Formula I donde A11, A12, A13 y A14 son N o CR11, CR12, CR13, CR14, respectivamente R1 es alquilo C1-C6, cicloalquilo C3-C6, entre otros R2 y R3 son H, F, entre otros R4 es H o alquilo C1-C6 R5 es H, hidroxietilo, entre otros R6, R7, R8, R9, R10, R11, R12, R13 y R14 son H, halogeno, entre otros R15 y R16 son H, alquilo C1-C6, entre otros. Son compuestos preferidos: N-(4-(1,1,1,3,3,3-hexafluoro-2-hidroxipropan-2-il)fenil)-2-(4-(metilsulfonil)fenil)acetamida 2-(4-(etilsulfonil)fenil)-N-(4-(1,1,1,3,3,3-hexafluoro-2-hidroxipropan-2-il)fenil)acetamida entre otros. Tambien se refiere a una composicion farmaceutica. Dichos compuestos son inhibidores de ROR gamma y son utiles en el tratamiento de enfermedades autoinmunes y enfermedades inflamatorias
