BIRAULT, VERONIQUE,CAMPBELL, AMANDA JENNIFER,HARRISON, STEPHEN ANTHONY,LE, JOELLE,SHUKLA, LENA
申请号：
PE0017802014
公开号：
PE24002014A1
申请日:
2013.04.25
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
Refers to a compound of formula (i), wherein R1 is selected from h, C1 - C3 alkyl R2, R3 and R4 are H is C1 - C3 alkyl R5, R6 is C3 C5 alkyl, cycloalkyl - CH2 - C3 - C4 R7 choosing of formula (ii) and (iii) R8 is Halo, c1-c6 alkoxy alkyl, cycloalkyl - C1 - C6 C3, C6, among ot Ros R9 is the Group (chr10 S - (-) - X (T) chr10) u - H is R10, R11, CH3, Oh, among others X is CH2, NH,Or R11 is heterocicloalquilo R is 0 - 2 0 - 2 S t is 0 - 1 u is 0 - 2. Preferred compounds are n - (2,4-dimethylphenyl) - N - (2-methylpropyl) - 3 - [(- 4 - ilmetoxi Oxan) methyl] benzene-1-sulfonamide n - (2,4-dimethylphenyl) - N - (2-methylpropyl) - 4 - [2 - (morpholin-4-yl) ethoxy] benzene-1-sulfonamide among others.It also relates to a Pharmaceutical composition that is useful in the treatment of inflammatory, Metabolic Diseases and Autoimmune mediated retinoideo Orphan receptor gamma (Rory).SE REFIERE A UN COMPUESTO DE FORMULA (IA), DONDE R1 SE SELECCIONA DE H, ALQUILO C1-C3, ENTRE OTROS R2, R3 Y R4 SON H R5 ES ALQUILO C1-C3 R6 ES ALQUILO C3-C5, -CH2-CICLOALQUILO C3-C4 R7 SE SELCCIONA DE LA FORMULA (II) Y (III) R8 ES HALO, ALQUILO C1-C6, ALCOXI C1-C6, CICLOALQUILO C3-C6, ENTRE OTROS R9 ES EL GRUPO -(CHR10)S-(X)T-(CHR10)U-R11 R10 ES H, CH3, OH, ENTRE OTROS X ES CH2, NH, O R11 ES HETEROCICLOALQUILO R ES 0-2 S ES 0-2 T ES 0-1 U ES 0-2. SON COMPUESTOS PREFERIDOS N-(2,4-DIMETILFENIL)-N-(2-METILPROPIL)-3-[(OXAN-4-ILMETOXI) METIL] BENCENO-1-SULFONAMIDA N-(2,4-DIMETILFENIL)-N-(2-METILPROPIL)-4-[2-(MORFOLIN-4-IL) ETOXI] BENCENO-1-SULFONAMIDA ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE ES UTIL EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS, METABOLICAS Y AUTOINMUNITARIAS MEDIADAS RECEPTOR HUERFANO RETINOIDEO GAMMA (RORY).
