CONTE, AURELIA,KUEHNE, HOLGER,LUEBBERS, THOMAS,MATTEI, PATRIZIO,MAUGEAIS, CYRILLE,MUELLER, WERNER,PFLIEGER, PHILIPPE
申请号：
ES07712126
公开号：
ES2392874T3
申请日:
2007.01.29
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of formula I wherein R1 is C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, C3-C8 cycloalkyl, C3-C8 trialkylsilyl or C1-C6 R2 is hydrogen or a group wherein R6 and R7 are independently hydrogen, C1-C6, C1-C6 haloalkyl, halogen, C3-C8cycloalkyl, OH or C1-C6 haloalkoxy R8 and R9 are independently hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, halogen, C3-C8cycloalkyl, OH or C1-C6 haloalkoxy X is CR12 or N 25 Y is CH or N wherein X and Y are not N at the same time R12 is hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, halogen, C3-C8cycloalkyl, OH or C1-C6 haloalkoxy R5 is hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, halogen, C3-C8cycloalkyl, OH or C1-C6 haloalkoxy R4 is hydrogen, or C1-C6 alkyl, C1-C6 haloalkyl, halogen, C3-C8 , OH or C1-C6 haloalkoxy, wherein at least one of R3, R5, R10 and R11 is not hydrogen A is CR10 or N B is CR11 or N D is CR3º N wherein -B> = Ay -A> = are not D-N> = N- R3 is hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, halogen, C3-C8cycloalkyl, OH or C1-C6 haloalkoxy R10 is hydrogen, or C1-C6 alkyl, C1-C6 haloalkyl, halogen, C3-C8cycloalkyl, OH or C1-C6 haloalkoxy, wherein at least one of R3, R4, R5 and R11 is not hydrogen R11 is hydrogen or C1-C6 alkyl, C1-C6 haloalkyl, halogen, C3-C8cycloalkyl, OH or C1-C6 haloalkoxy, when at least two of R3, R4, R5 and R10 are not hydrogen wherein at least two of R3, R4, R5, R10 and R11 are not hydrogen n is 1, 2 or 3 and pharmaceutically acceptable salts thereof.Un compuesto de fórmula I en el que R1 es alquilo C1-C6, haloalquilo C1-C6, haloalcoxi C1-C6, cicloalquilo C3-C8, halocicloalquilo C3-C8 o trialquilsililo C1-C6 R2 es hidrógeno o un grupo en los que R6 y R7 son independientemente hidrógeno, alquilo C1-C6, haloalquilo C1-C6, halógeno, cicloalquilo C3-C8, OH o haloalcoxi C1-C6 R8 y R9 son independientemente hidrógeno, alquilo C1-C6, haloalquilo C1-C6, halógeno, cicloalquilo C3-C8, OH o haloalcoxi C1-C6 X es CR12 o N 25 Y es CH o N en el que X e Y no son N al mismo tiempo R12 es hidrógeno, alquilo C1-C6, haloalquilo C
