KYM, Philip R.,WANG, Xueqing,SEARLE, Xenia B.,LIU, Bo,YEUNG, Ming C.,ALTENBACH, Robert J.,VOIGHT, Eric,BOGDAN, Andrew,KOENIG, John R.
申请号：
PE0007642017
公开号：
PE11062017A1
申请日:
2015.10.28
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
Refers to a compound of formula I, where X is CR2 and Cr3 or X is N and x CR2 and Cr3 is and N M is 0, 1, 2 or 3 R is Halogen, C1 - C6 haloalquilo or c1-c6 alkyl R1 and R2 are Hydrogen, halogen, among others and R3 R14 are Hydrogen, halogen, among others R4 is Hydrogen, C1 - C6 haloal Chyle or c1-c6 alkyl R5 is Hydrogen, C1 - C6 haloalquilo,Among others, or R4 and R5 together form a cycloalkyl or Heterocyclic C3 C6 4-6 members R4 is Hydrogen, halogen, among others R7 is Hydrogen, halogen, among others R8 is Hydrogen, C1 - C6 haloalquilo or c1-c6 alkyl R9, R10 and R13 are Hydrogen, halogen, inter other R11 and R12 are Hydrogen, C 1 - C3 alkyl or Halogen.Preferred compounds are: acid, 3 - [(2R, 4R) - 4 - ({[1 - (2,2 - difluoro - 1,3-benzodioxol-5-yl) cyclopropyl] carbonyl] amino) - 7 - methoxy - 3,4-dihydro - 2H - cromen - 2 - il] benzoic acid, 3 - [(2R, 4S) - 4 - ({[1 - (2,2 - difluoro - 1,3-benzodioxol-5-yl) cyclopropyl] carbonyl] amino) - 7 - methoxy - 3,4-dihydro - 2H - cromen - 2 - il] benzoic acid among others. It also relates to a Pharmaceutical Composition and a method of treatment.These compounds are modulators of Protein transmembrane conductance regulator (CFTR), cystic fibrosis, being useful in the treatment of diseases is Modulated by the ProteinSe refiere a un compuesto de formula I, donde: X es CR2 y Y es CR3 o X es N y Y es CR3 X es CR2 y Y es N m es 0, 1, 2 o 3 R" es halogeno, C1-C6 haloalquilo o C1-C6 alquilo R1 y R2 son hidrogeno, halogeno, entre otros R3 y R14 son hidrogeno, halogeno, entre otros R4 es hidrogeno, C1-C6 haloalquilo o C1-C6 alquilo R5 es hidrogeno, C1-C6-haloalquilo, entre otros o R4 y R5 juntos forman un cicloalquilo C3-C6 o heterociclo de 4-6 miembros R6 es hidrogeno, halogeno, entre otros R7 es hidrogeno, halogeno, entre otros R8 es hidrogeno, C1-C6 haloalquilo o C1-C6 alquilo R9, R10 y R13 son hidrogeno, halogeno, entre otros R11 y R12 son hidrogeno, C1-C3 alquilo o halogeno. Son compuestos preferidos: acido 3-[(2R,4R)-4-({[1-(2,
