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Octahydro-cyclopentapyrrolyl antagonists of CCR2
专利权人:
Janssen Pharmaceutica NV
发明人:
Chaozhong Cai,David F. McComsey,Zhihua Sui,Fu-An Kang
申请号:
US13943099
公开号:
US09024017B2
申请日:
2013.07.16
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present invention comprises compounds of Formula (I).wherein: R1, R2, R3, R4, R5, Z1 and Z2 are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
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