Andrew Thomas;Matthew C. Lucas;Roland Jakob-Roetne
发明人:
Roland Jakob-Roetne,Matthew C. Lucas,Andrew Thomas
申请号：
US12766202
公开号：
US08227461B2
申请日:
2010.04.23
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention is concerned with novel isoxazole derivatives of formula Iwherein X, R1, R2, R3, R4 and R5 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of the present invention have affinity and selectivity for GABA A α5 receptor. Further the present invention is concerned with the manufacture of the active compounds of formula I, pharmaceutical compositions containing them and their use as pharmaceuticals.
