Andrew Thomas,Mattew C. Lucas,Roland Jakob- Roetene
申请号：
BRPI1016192
公开号：
BRPI1016192A8
申请日:
2010.04.27
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The present invention is concerned with novel isoxazole derivatives of formula I wherein X, R1, R2, R3, R4 and R5 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of the present invention have affinity and selectivity for GABA A &alpha；5 receptor. Further the present invention is concerned with the manufacture of the active compounds of formula I, pharmaceutical compositions containing them and their use as pharmaceuticals.
