JAKOB-ROETNE, ROLAND,LUCAS, MATTHEW, C.,THOMAS, ANDREW
申请号：
CA2750678
公开号：
CA2750678C
申请日:
2010.04.27
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention is concerned withnovel isoxazole derivatives of formula (I), wherein X, R1,R2, R3, R4 and R5 are as described herein, as well as pharmaceuticallyacceptable salts and esters thereof. The activecompounds of the present invention have affinity andselectivity for GABA A .alpha.5 receptor. Further the presentinvention is concerned with the manufacture of the activecompounds of formula I, pharmaceutical compositionscontaining them and their use as medicaments.
