COMPOSITIONS AND METHODS FOR INHIBITING STIMULATOR OF INTERFERON GENE DEPENDENT SIGNALLING

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专利权人:

发明人:

DUBENSKY THOMAS W JR,KANNE DAVID B

申请号：

IN2657/MUMNP/2015

公开号：

IN2015MN02657A

申请日:

2015.09.12

申请国别(地区):

IN

年份:

2016

代理人:

摘要：

The present invention provides cyclic di nucleotide (CDN) compounds that inhibit signaling at a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides which inhibit STING dependent TBK1 activation and the resulting production of type I interferon.

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中国工程科技知识中心

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