Katibah, George Edwin,Kanne, David,Sung, Leonard,Gauthier, Kelsey,Glickman, Laura Hix,Leong, Justin,McWhirter, Sarah M.,Dubensky, Thomas W.,McKenna, Jeffrey,Canham, Stephen M.,Ndubaku, Chudi Obi
申请号：
AU2016343993
公开号：
AU2016343993A1
申请日:
2016.10.28
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce human STING-dependent type I interferon production, wherein the cyclic purine dinuclotides present in the composition are 2'- or 3'-mono-fluoro substituted, or 2'3'-di-fluoro substituted mixed linkage 2',5' - 3',5' CDNs.
